Diabetes mediates the relationship between cardiometabolic index and kidney stones: a cross-sectional study
December 28, 2024 / Cardiometabolic Index / Kidney Stones / Glycemic Control Kidney Health
Elevated Cardiometabolic Index (CMI) is significantly associated with increased kidney stone risk, with diabetes mediating 15.3% of the relationship. Lowering CMI and improving glycemic control may reduce kidney stone incidence.
Outcomes and complications after long versus short gastric pouch Roux-en-Y gastric bypass in patients with severe obesity
December 28, 2024 / Roux-en-Y gastric bypass outcomes / Bariatric Surgery Weight Loss Results / Obesity Treatment Comparison
Short gastric pouch Roux-en-Y gastric bypass (RYGB) shows slightly better weight loss outcomes than long pouches after 12 months, but both approaches are equally effective and safe for treating severe obesity and associated medical conditions.
Phytochemical composition and antidiabetic, anti-obesity, antioxidant, and cytotoxic activities of Carthamus tinctorius seed oil
December 28, 2024 / Carthamus tinctorius seed oil benefits / Safflower Oil Antidiabetic Effects / Anti-Obesity Natural Remedies / Cytotoxic Activity
Carthamus tinctorius (safflower) seed oil contains potent linoleic acid and exhibits antioxidant, anti-obesity, antidiabetic, and cytotoxic properties. It inhibits oxidative stress, pancreatic lipase, and α-amylase activity, highlighting its therapeutic potential against metabolic and cancer-related conditions.
The interplay between lying, sitting, standing, moving, and walking on obesity risk in older adults: a compositional and isotemporal substitution analysis
December 28, 2024 / Obesity Risk in Older Adults / Benefits of Walking / Sedentary Behavior and BMI / Aging Health
Replacing sedentary behaviors like lying or sitting with movement or walking can reduce BMI in older adults, highlighting the importance of low-intensity physical activity in managing obesity risk and promoting healthier aging.
Intermittent fasting as a treatment for obesity in young people: a scoping review
December 30, 2024 / Intermittent Fasting / Youth Obesity / Weight Loss / Obesity Management / Cardiometabolic Outcomes / Fasting
Intermittent fasting shows promise as a treatment for obesity in young people, improving weight loss and cardiometabolic outcomes. However, more rigorous studies are needed to assess its feasibility, adherence, and long-term effects in this age group.
How Does Weight Loss Improve Insulin Sensitivity in Type 2 Diabetes?
December 27, 2024 / Weight Loss / Insulin Sensitivity / Ceramide Metabolism / Type 2 Diabetes / Skeletal Muscle Insulin Resistance / Obesity Management
Weight loss improves insulin sensitivity in type 2 diabetes by reducing mitochondrial ceramide levels, potentially alleviating stress in metabolic pathways. Targeting ceramide metabolism may offer new therapeutic options for managing obesity and diabetes.
Brd4 modulates metabolic endotoxemia-induced inflammation by regulating colonic macrophage infiltration in high-fat diet-fed mice
December 28, 2024 / Brd4 and Metabolic Inflammation / Ccr2 and Ccr5 in Obesity / Metabolic Endotoxemia Regulation / Insulin Resistance
Brd4 drives colonic macrophage infiltration and inflammation in high-fat diet-induced obesity by upregulating Ccr2 and Ccr5 expression. Reducing Brd4 activity mitigates inflammation, metabolic endotoxemia, and insulin resistance, suggesting Brd4 as a potential therapeutic target.
Prevalence of anemia among women of reproductive age in China
December 30, 2024 / Anemia / Chinese Women / Women’s Health / Obesity / Metabolic Health
Anemia affects 15.8% of reproductive-age women in China, with geographic and age-related variations. Overweight and obesity correlate with moderate anemia, emphasizing the need for targeted interventions addressing both metabolic factors and regional disparities.
Risk factors for metabolic syndrome in the premetabolic state assessed using hierarchical clustering study in a health screening group
December 28, 2024 / Metabolic Syndrome Risk Factors / Premetabolic State Detection / Machine Learning / MetS Prevention
Machine learning identified clusters at high metabolic syndrome (MetS) risk in premetabolic individuals, with elevated uric acid, C-reactive protein, and resting heart rate being key predictors. Early intervention in high-risk clusters could mitigate MetS progression.
The impact of metabolic component count on IgA nephropathy prognosis
December 28, 2024 / Metabolic Syndrome / IgA Nephropathy / Hypertension Impact / Kidney Health / Metabolic Health
Metabolic syndrome components, particularly hypertension, worsen IgA nephropathy (IgAN) prognosis by increasing proteinuria and reducing eGFR. More metabolic abnormalities correlate with poorer renal outcomes, emphasizing the need for comprehensive metabolic management in IgAN patients.
Elevated triglyceride glucose index is associated with advanced cardiovascular kidney metabolic syndrome
December 28, 2024 / TyG Index / CKM Syndrome / Insulin Resistance Marker / Advance CKM Syndrome Risk Factors / Cardiovascular-kidney-metabolic health
Elevated triglyceride glucose (TyG) index is strongly associated with advanced Cardiovascular-Kidney-Metabolic (CKM) syndrome, highlighting its utility as a cost-effective tool for assessing insulin resistance and predicting CKM syndrome risk in clinical settings.
Exercise and Diet Combine to Improve Liver Health in People With MASH
December 30, 2024 / MASH / Liver Health Improvement Strategies / MASH Lifestyle Intervention / Liver Disease / Insulin Sensitiivity / Calorie Restriction
A combined 10-month exercise and calorie-restricted diet significantly improved liver health, insulin sensitivity, and reduced liver fat in MASH patients. This study supports integrating aerobic exercise and diet in MASH management for enhanced outcomes.
Persistent Short Sleep During Pregnancy Linked to Metabolic Syndrome
December 30, 2024 / Pregnancy Short Sleep / Pregnancy Metabolic Syndrome / Postpartum Sleep Duration Health Risks
Persistent short sleep during pregnancy and postpartum is linked to a 60% increased risk of metabolic syndrome. This underscores the need for targeted sleep health interventions to reduce adverse outcomes and address health disparities.
Monocytes to Apolipoprotein A1 ratio is associated with metabolic dysfunction-associated fatty liver disease in type 2 diabetes mellitus
December 28, 2024 / Monocyte-to-Apolipoprotein A1 ratio (MAR) / MASLD / Type 2 Diabetes / Fatty Liver Disease / Metabolic Liver Disease
The monocyte-to-Apolipoprotein A1 ratio (MAR) is a strong independent predictor of metabolic dysfunction-associated fatty liver disease (MASLD) in type 2 diabetes mellitus (T2DM), outperforming other markers in diagnostic accuracy for early MASLD identification.
Association between the triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes mellitus in non-alcoholic fatty liver disease
December 28, 2024 / TG/HDL-C Ratio / Diabetes Risk / Lipid Biomarkers in NAFLD and T2DM / Insulin Resistance
The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is a strong predictor of type 2 diabetes mellitus (T2DM) risk in non-alcoholic fatty liver disease (NAFLD) patients, outperforming individual lipid parameters in identifying at-risk individuals.
Uncovering metabolic dysregulation in schizophrenia and cannabis use disorder through untargeted plasma lipidomics
December 28, 2024 / Lipidomics in Schizophrenia / Metabolic Dysregulation / Biomarkers / Amino Acids / Mental Healthe
Plasma lipidomic analysis revealed disrupted lipid metabolism in schizophrenia, cannabis use disorder, and dual diagnoses, with reduced acylcarnitines and altered N-acyl amino acids linked to metabolic dysregulation, suggesting lipid biomarkers as potential therapeutic targets.
Investigating fatty acid metabolism in hepatocellular carcinoma patients
December 30, 2024 / Fatty Acid Metabolism in HCC / Hepatocellular Carcinoma Metabolic Reprogramming / Liver Cancer
Fatty acid metabolism reprogramming contributes to hepatocellular carcinoma (HCC) heterogeneity. Epithelial cells show the most metabolic aberrance. Low FA metabolism correlates with poor prognosis, highlighting its potential as a therapeutic target in liver cancer.
Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors
December 27, 2024 / Shared Genetics in Cardiovascular Diseases / Cardiometabolic Risk Factors / CVD / Blood Pressure / Vascular Disease
Shared genetic loci linked to cardiovascular and cerebrovascular diseases (CVDs and CeVDs) were identified, with blood pressure, lipids, and carotid thickness as common cardiometabolic risk factors. These findings support targeting genetic pathways for therapy and prevention.
FDA Approves Zepbound for Sleep Apnea in Patients With Obesity
December 24, 2024 / FDA / Zepbound / Tirzepatide / Obestructive Sleep Apnea / Obesity / OSA Management / Eli Lilly / Clinical Trials
The FDA approved Zepbound (tirzepatide), a GLP-1 receptor agonist, for moderate-to-severe obstructive sleep apnea (OSA) in obese patients, demonstrating significant symptom improvement in clinical trials alongside lifestyle changes.