Perinatal obesity primes the hepatic metabolic stress response in the offspring across life span
February 21, 2025 / Perinatal Obesity / Liver Obesity / Oxidative Stress / Chronic Liver Disease
Perinatal obesity alters offspring liver metabolism across their lifespan, increasing oxidative stress and modifying lipid metabolism. Despite early-life weight gain, a compensatory mechanism prevents steatosis. However, metabolic programming may heighten susceptibility to chronic liver disease later in life.
URI study addresses disparities in obesity treatment for Hispanic-Latino communities
February 24, 2025 / Obesity Treatment / Metabolic and Bariatric Surgery / Hispanic-Latino Health / Obesity Stigma
A URI study explores low rates of metabolic and bariatric surgery (MBS) in Hispanic-Latino communities, identifying socio-cultural barriers and healthcare access issues. Findings aim to improve patient-provider communication, reduce stigma, and develop culturally relevant obesity treatment education.
Europe sets new standards for obesity surgery medical tourism
February 19, 2025 / Obesity Surgery Guidelines / Bariatric Medical Tourism / Patient Safety Standards / Metabolic Surgery Regulations / Post-Operative Care
New European guidelines set safety standards for obesity surgery medical tourism, addressing regulation, post-operative care, eligibility, and patient rights. Developed by healthcare professionals and patient groups, the recommendations aim to reduce complications, improve follow-up care, and enhance patient safety.
Review uncovers link between metabolic disorders and Alzheimer’s disease
February 19, 2025 / Alzheimer’s Disease / Metabolism / Dementia / Lipid Meatbolism / Cognitive Decline Prevention
A review highlights links between metabolic syndrome (diabetes, obesity, hypertension, dyslipidemia) and Alzheimer’s disease, emphasizing lipid metabolism’s role in neurodegeneration. Findings suggest potential treatment targets, including cholesterol-lowering drugs and dietary interventions, to mitigate cognitive decline.
Semaglutide ameliorates metabolic disorders in offspring via regulation of oocyte ROS of pre-pregnancy obesity mice
February 21, 2024 / Semaglutide / Pregnancy / Obesity Treatment / Oxidative Stress / Fertility / Women’s Health
Semaglutide treatment before pregnancy improves metabolic health in offspring of obese mice by reducing oxidative stress in oocytes. The protective effects, mediated via the PI3K/AKT pathway, highlight semaglutide’s potential in preventing obesity-related metabolic disorders across generations.
Unveiling The Link Between Macrophage Metabolism And Obesity
February 20, 2025 / Macrophage Metabolism / Obesity / AMPK / Immunometabolism
A study reveals how macrophage metabolism influences obesity, showing that AMPK inhibition promotes SUCLA2 activity, succinate accumulation, and IL-1β-driven inflammation. Targeting the AMPK-SUCLA2-IL-1β pathway may offer new therapeutic strategies for obesity and metabolic inflammation.
Inflammation and metabolic syndrome contribute to prostate enlargement in aging men
February 19, 2025 / Inflammation / Prostate Health / Metabolic Syndrome / Oxidative stress
A study links inflammation and metabolic syndrome to benign prostatic hyperplasia (BPH) in aging men. Elevated inflammatory markers worsen prostate enlargement, especially in those with poor metabolic health. Future research may explore anti-inflammatory treatments and lifestyle interventions for BPH management.
Algorithm spots people with MASLD, MASH using health records
February 24, 2025 / MASLD Diagnosis Algorithm / Fatty Liver Disease / MASH / Fibrosis Screening / AI / Electronic Health Records
Researchers developed an algorithm to detect metabolic dysfunction-associated steatotic liver disease (MASLD) and fibrosis using electronic health records. It identifies undiagnosed cases, aiding early intervention. Validated across U.S. healthcare systems, the tool may enhance MASLD diagnosis and patient management.
Promising Potential for FGF21 Analogs in MASH Management
February 19, 2025 / FGF21 Analogs for MASH / Liver Fibrosis Treatment / Fatty Liver Disease Treatment / Hepatic Fat Reduction Strategies
FGF21 analogs significantly improve fibrosis and resolve MASH without progression, particularly in non-cirrhotic patients. A meta-analysis shows these therapies enhance hepatic fat reduction and metabolic function with a favorable safety profile, supporting their potential as future MASH treatments.
First 5 regions chosen to focus innovative effort on diagnosing, treating CKM syndrome
February 18, 2024 / CKM Syndrome Diagnosis / Cardiovascular-kidney-metabolic health / Chronic Disease Management
A new American Heart Association initiative will improve cardiovascular-kidney-metabolic (CKM) syndrome care in five U.S. regions by enhancing screening, promoting collaborative care, and addressing social determinants of health. The effort aims to streamline treatment and improve patient outcomes.
Correlation between gut microbiota dysbiosis, metabolic syndrome and breast cancer
February 24, 2025 / Gut Microbiome / Breast Cancer / Metabolic Syndrome / Cancer Risk
A study links metabolic syndrome and gut microbiota dysbiosis to increased breast cancer risk. Breast cancer patients had lower Lactobacillus and Bifidobacterium levels, suggesting gut microbiome alterations may contribute to cancer progression. Further research may inform preventive and therapeutic strategies.
User-friendly portal links molecular and clinical data to boost metabolic disease research
February 20, 2025 / Adipose Tissue Reaserch / Obesity / Metabolic Disease / Molecular Data / Single-cell Transcriptomics Portal
Researchers developed Adiposetissue.org, a user-friendly portal integrating molecular and clinical data from 6,000+ individuals. It enables exploration of adipose tissue biology, obesity, and metabolic diseases, offering advanced analysis tools for researchers without bioinformatics expertise. Future updates will expand available datasets.
Long-Term Cardiovascular and Metabolic Health Outcomes of Gestational Diabetes Mellitus: A Systematic Review
February 24, 2025 / Gestational Diabetes / Long-term Effects / GDM / Metabolic Syndrome / Maternal Health / Diabetes Risk
A systematic review confirms that gestational diabetes mellitus (GDM) increases long-term risks for type 2 diabetes, hypertension, and metabolic syndrome in mothers, while offspring face obesity, insulin resistance, and cardiovascular disease. Early detection, lactation, and lifestyle interventions may mitigate risks.
ZHX2 inhibits diabetes-induced liver injury and ferroptosis by epigenetic silence of YTHDF2
February 22, 2025 / Diabetes / Liver Injury / MASLD / Metabolic Dysfunction / Liver Disease
Researchers identified the ZHX2-YTHDF2-ferroptosis pathway as a key regulator in diabetes-induced liver injury. ZHX2 overexpression reduces ferroptosis and protects the liver, suggesting that targeting this pathway may offer a therapeutic strategy for metabolic dysfunction-associated steatotic liver disease (MASLD).
SGK1 Link To Diabetes-Associated Cognitive Dysfunction Uncovered
February 22, 2025 / SGK1 / Cognitive Dysfunction / Diabetes / Brain Health
A study links SGK1 overexpression to demyelination and cognitive decline in diabetic mice, identifying it as a potential therapeutic target for diabetes-associated cognitive dysfunction (DACD). SGK1 inhibition reversed cognitive deficits, suggesting possible remyelination-based treatments for neuroprotection.
Burden of cardiometabolic diseases and depression in a low-income, urban community in Pakistan: a cross-sectional survey
February 24, 2025 / Cardiometabolic Disease / Pakistan / Hypertension / Urban Health Disparities
A survey in urban Pakistan found a high burden of cardiometabolic diseases (CMDs), with hypertension (34%) being most prevalent. CMDs were strongly linked to depression and financial strain, highlighting the need for integrated physical, mental, and economic health interventions.
Veradigm Introduces Cardiometabolic Clinical Registry Datasets to Enhance the Next Generation of Real-World Research
February 18, 2025 / Cardiometabolic Clinical Registries / HER Data / Cardiology Research
Veradigm has launched seven cardiometabolic clinical registry datasets, integrating structured and unstructured EHR data to advance real-world research. Using Natural Language Processing (NLP), the registries provide insights into heart failure, diabetes, hypertension, and chronic kidney disease for life science and public health research.
Scientists uncover new information on the link between air pollution exposure and dementia risk — here’s what you need to know
February 22, 2024 / Air Pollution / Dimentia Risk / Cardiometabolic Disease / Cognitive Decline / Brain Health / Dementia
A study links air pollution exposure to increased dementia risk in cardiometabolic disease (CMD) patients, with pollutants like PM2.5 and nitrogen oxides playing key roles. However, healthy lifestyle choices, including exercise and not smoking, may help reduce this risk.