Obesity and metabolic syndrome affect breast cancer risks differently, study reports
May 13, 2024 / Obesity / Metabolic Syndrome / Breast Cancer / Diet
A higher metabolic syndrome score was associated with higher mortality from breast cancer and obesity was associated with a higher incidence of breast cancer, according to a studyTrusted Source published today in the journal Cancer.
Vit D and probiotic juice supports metabolic health in obesity
May 13, 2024 / Vitumin D / Metabolic Health / Obesity / Cardiometabolic / Weight Loss
To address obesity, studies have investigated innovative dietary interventions harnessing the combined effects of bioactive substances, including vitamin D and probiotics.
Intermittent fasting protects against fatty liver disease in mouse models
May 13, 2024 / Fasting / Fatty Liver Disease / Mice / MASH
An intermittent fasting regimen reduced liver fat buildup and lowered the likelihood of liver cancer in mouse models of metabolic dysfunction-associated steatohepatitis (MASH), a severe form of fatty liver disease, a new study reports.
Western diet linked to chronic diseases by gut microbiota disruption
May 13, 2024 /
An article published in the journal Best Practice & Research Clinical Gastroenterology provides an in-depth overview of the Western diet’s impact on modulating gut microbiota and gut barrier functionality and subsequently increasing the risk of non-communicable chronic diseases.
Landmark study sheds new light on the heterogeneity of type 2 diabetes
May 13, 2024 / Type 2 Diabetes
A landmark study by the DZD, published in ‘The Lancet Diabetes & Endocrinology’, sheds new light on the heterogeneity of type 2 diabetes. The researchers employed an innovative algorithm to stratify people with type 2 diabetes using routine data and thus visualize the metabolic diversity of diabetes.
Working night shift thrice weekly increases diabetes, obesity risks
May 12, 2024 / Diabetes / Obesity Risks / Drug Developing
While some people might willingly opt to work at night or are compelled to work at such unsociable hours to earn a living, a new study has revealed that such work arrangement, when done three times a week may be sufficient to increase the chances of developing diabetes, obesity, and other metabolic disorders, among other ailments.
Dapagliflozin added to metformin reduces perirenal fat layer in type 2 diabetic patients with obesity
May 11, 2024 / Type 2 Diabetes / Insulin Resistance / Weight Loss
Sodium-glucose co-transporters type 2 inhibitors (SLGT2i) are highly effective in controlling type 2 diabetes, but reported beneficial cardiovascular effects suggest broader actions on insulin resistance. Weight loss may be initially explained by glycosuria-induced net caloric output and secondary volumetric reduction, but its maintenance could be due to loss of visceral fat mass.
The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis
May 10, 2024 / Cardio-Metabolic Health / MASH / Blood Pressure
Lanifibranor, a pan-PPAR agonist, improves liver histology in patients with metabolic dysfunction-associated steatohepatitis (MASH), who have poor cardiometabolic health (CMH) and cardiovascular events as major mortality cause. NATIVE trial secondary and exploratory outcomes (ClinicalTrials.gov NCT03008070) were analyzed for the effect of lanifibranor on IR, lipid and glucose metabolism, systemic inflammation, blood pressure (BP), hepatic steatosis (imaging and histological grading) for all patients of the original analysis.
Modeling the interaction between the intestine and liver in a multi-organ microphysiological system for studying metabolic-dysfunction associated steatotic liver disease
May 10, 2024 /Liver Disease / Cancer / Fibrosis
When homeostasis is disturbed, changes in dietary factors and microbiota can impact intestinal barrier function. This can result in the release of microbial metabolites and components that move to the liver, contributing to inflammation, fibrosis, and cancer.
Enlarged Lymph Nodes on Screening Mammograms Predict Cardiometabolic Disease, Cardiovascular Risk
May 10, 2024 / Lymph Nodes / Cardiovascular Risk / Cardiometabolic Disease / Type 2 Diabetes / Hypertension
According to the Summa Cum Laude Award-Winning Online Poster presented during the 124th ARRS Annual Meeting, fat-enlarged axillary nodes on screening mammograms can predict high cardiovascular disease (CVD) risk, Type 2 diabetes (T2DM), and hypertension (HTN).
5 Prime Sciences, Lilly Partner to Advance Cardio-Metabolic Disease Drug Development
May 9, 2024 / Eli Lilly / Drug Development / Metabolic Diseases
5 Prime Sciences, a biotechnology data analytics company focused on using human genetics to accelerate drug development, has entered a strategic collaboration with Eli Lilly and Company dedicated to accelerating target discovery and early development in the field of cardio-metabolic diseases.
‘Surprisingly’ high number of adults in the U.S. at risk of heart syndrome
May 8, 2024 / Cardiovascular Health / Heart Disease / New Study
While the unexpectedly high number doesn’t mean that the majority of adults in the U.S. have full-blown heart disease, it does indicate that many are at risk of developing the condition, even younger people.
Nearly 90% of Adults in U.S. Have Syndrome That Can Lead to Heart Disease
May 8, 2024 / Heart Disease / Cardiovascular-kidney-metabolic syndrome / Diabetes / Obesity
The American Heart Association (AHA) introduced a new staging systemTrusted Source in 2023 — called CKM syndrome — to better treat and manage cardiovascular, kidney, and metabolic diseases, since they are deeply connected and often require a multidisciplinary approach.
CKM syndrome Trusted Sourceis a systemic disorder that has links between heart disease, kidney disease, diabetes, and obesity.
Cell therapy fails to slow early type 1 diabetes, but safety is established
May 8, 2024 / Cell Therapy / Type 1 Diabetes / Pancreas / Insulin
Tolerance is the holy grail in calming autoimmune disease, a truce in the immune system’s faulty battle against the body’s own fabric. In type 1 diabetes, immune fighters attack beta cells in the pancreas that produce insulin, the hormone that controls glucose levels in the blood.
Sciwind Biosciences & HK inno.N ink $56 M deal to treat metabolic diseases in Korea
May 7, 2024 / Sciwind Biosciences / Metabolic Diseases / Korea
Sciwind Biosciences Co., a clinical stage biopharmaceutical company focused on developing treatments for metabolic disease, and HK inno.N Corporation, a South Korean commercial stage pharmaceutical company, have announced a licensing and partnership agreement for the development and commercialisation of ecnoglutide injection (XW003), a novel GLP-1 analog for the treatment of type 2 diabetes, obesity and metabolic dysfunction-associated steatohepatitis (MASH), in South Korea.
Missing link between diet and cancer risk uncovered as diabetes damages DNA
May 7, 2024 / Cancer Risk / Diabetes / Diet
Diet and metabolic disorders such as diabetes increase the risk of cancer, a study found.
Research from the Cancer Science Institute of Singapore found high glucose levels can temporarily disable the BRCA2 gene, known for its tumor-suppressing abilities.