Gene Therapy Transforms Harmful Fats Into Beneficial Omega-3s
October 14, 2024 / Gene Therapy for Obesity / Omega-3 Conversation / Childhood Obesity Treatment / Metabolic Health
Shriners Children’s St. Louis has developed a gene therapy that converts harmful Omega-6 fatty acids into beneficial Omega-3s, improving metabolic health and reducing obesity-related conditions like arthritis in children, with promising potential for broader health applications.
Gene Therapy Method Converts Omega Fatty Acids to Combat Childhood Obesity
October 14, 2024 / Gene Therapy / Childhood Obesity / Fatty Acid Metabolism
Shriners Children’s St. Louis researchers have developed a gene therapy that converts harmful Omega-6 fatty acids into beneficial Omega-3s, improving metabolic health and reducing obesity-related issues like arthritis in children. Clinical trials are expected within 3-5 years.
New nanoparticle system fights obesity
October 14, 2024 / Nanoparticle Obesity Treatment / Fat Absorption Reduction / Obesity Therapy
A novel nanoparticle system targeting the enzyme SOAT2 in the small intestine effectively reduces fat absorption, preventing diet-induced obesity in mice. This non-invasive therapy shows promise as a safer, patient-friendly alternative for obesity treatment.
Diagnosis and Management of Lean Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Systematic Review
October 14, 2024 / MASLD Diagnosis / Fatty Liver Disease / Metabolic Liver Disease
Lean MASLD, a form of liver disease in non-obese individuals, complicates diagnosis and management due to its atypical presentation. A systematic review highlights the need for personalized diagnostic approaches and treatments targeting metabolic dysfunction, rather than relying solely on obesity markers.
Study identifies role of metabolic risk factors in onset of diabetes among people with HIV
October 14, 2024 / HIV Diabetes Risk / Metabolic Risk Factors / Pitavastatin / Diabetes / Obesity
A study shows that metabolic risk factors, including obesity and prediabetes, significantly increase diabetes risk in HIV patients treated with pitavastatin or placebo. Targeting these factors through lifestyle interventions may help prevent diabetes in this population.
Lifechanging drug successfully reduces weight and cholesterol levels
October 13, 2024 / Nanogel Weight Loss Therapy / Obesity / Cholesterol Reduction Drug / Cardiometabolic Treatment / Liver Drug Delivery
Researchers at UMass Amherst developed a nanogel-based drug delivery method using thyromimetic hormones, which effectively reduced weight, cholesterol, and liver inflammation in mice without side effects, offering promise for treating obesity and cardiometabolic disorders.
Ketone body metabolism and cardiometabolic implications for cognitive health
October 11, 2024 / Ketone Body Metabolism / Cardiometabolic Diseases / Cognitive Health / Insulin Resistance
Ketone body metabolism links cardiometabolic diseases and neurodegenerative conditions, like cognitive decline. It offers therapeutic potential by regulating substrate utilization in both physiological and pathological conditions, providing insights for treating metabolic and brain-related disorders.
Mercy Fort Smith Metabolic and Bariatric Surgery Center to host Walk from Obesity on Saturday
October 11, 2024 / Obesity Awareness / Bariatric Surgery Support / Obesity Prevention
Mercy Fort Smith Metabolic and Bariatric Surgery Center will host its first “”Walk from Obesity”” event, raising awareness and funds for obesity treatment and research. The event features a one-mile walk and 5K run, supporting community involvement and obesity prevention.
Eli Lilly and insitro collaborate to advance new treatments for metabolic diseases
October 11, 2024 / Eli Lilly / MASLD / Drug Development siRNA Liver Therapy
Eli Lilly and insitro have partnered to develop new treatments for metabolic diseases, including MASLD, using insitro’s AI/ML platform. The collaboration combines siRNA molecules, antibody discovery, and GalNAc technology to target liver diseases at a molecular level.
Metabolic syndrome factors linked to increased bowel cancer risk
October 10, 2024 / Metabolic Syndrome / Bowel Cancer Risk / Obesity / Cancer / Insulin Resistnce
Metabolic syndrome factors—like obesity, high blood pressure, and insulin resistance—are linked to an increased risk of bowel cancer. Addressing metabolic health through preventive measures could reduce cancer risk alongside standard screening.
The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer
October 10, 2024 / Obesity / Cancer Risk / Dietary Fiber / Chronic Disease Prevention
Dietary fibers, fermented by the gut microbiome, modulate microbial ecology and influence health outcomes. They are linked to reduced risks of obesity, cardiometabolic diseases, and cancer, but individual responses vary, highlighting the need for further microbiome-focused research.
Scientists reveal strong connection between zinc levels and Type 2 Diabetes
October 10, 2024 / Type 2 Diabetes / Zinc / Metabolic Function /
A new study reveals a strong link between zinc levels and the risk of type 2 diabetes and non-alcoholic fatty liver disease, highlighting zinc’s critical role in metabolic health and offering potential therapeutic targets for these conditions.
BYU study finds diesel exhaust can contribute to poor metabolism, weight gain
October 10, 2024 / Weight Gain / Air Pollution / Insulin Resistance / Metabolic Diseases
A BYU study found that exposure to diesel exhaust contributes to metabolic diseases by increasing fat mass, insulin resistance, and inflammation, potentially leading to obesity, diabetes, and heart disease, highlighting non-dietary factors in metabolic health.
Eating less can lead to a longer life: massive study in mice shows why
October 9, 2024 / Immune Health Lifespan / Weight Loss / Dietary Restriction / Metabolic Changes
A large study on mice shows that caloric restriction increases lifespan through factors beyond weight loss and metabolism, including immune health and genetic resilience. This challenges conventional views on how calorie reduction promotes longevity.
New research offers hope for treating metabolic dysfunction-associated liver disease
October 9, 2024 / MASLD Treatment / Liver Regneration / MASH Liver Disease
New research suggests inhibiting the enzyme ACMSD can boost NAD+ levels, reducing inflammation, DNA damage, and fibrosis in metabolic dysfunction-associated liver disease (MASLD/MASH). This discovery offers a promising therapeutic target for treating liver damage caused by these conditions.
Weight-loss surgery may lower risk of pancreatic cancer in people with obesity
October 9, 2024 / Weight-Loss / Pancreatic Cancer / Bariatric Surgery Cancer Prevention / Obesity Risk / Type 2 Diabetes
A meta-analysis shows that weight-loss surgery significantly reduces pancreatic cancer risk in people with obesity, especially those with type 2 diabetes. The surgery cuts the risk by 44% in obesity alone and by 79% in those with both conditions.
Metabolic-Bariatric Surgery Tied to Reduced Risk for Pancreatic Cancer in Those With Obesity
October 9, 2024 / Type 2 Diabetes / Obesity Surgery Benefits / Bariatric Surgery Cancer Prevention
A review reveals that metabolic-bariatric surgery (MBS) reduces pancreatic cancer risk in individuals with obesity, particularly those with type 2 diabetes (T2D). The protective effect is evident across various surgery types, with stronger benefits in T2D patients.
Electro-acupuncture shows promise in obesity management
October 8, 2024 / Obesity Management Therapy / Weight Loss / Acupuncture Metabolic Benefits
Electro-acupuncture may help manage obesity by targeting osteoprotegerin, a protein involved in fat cell formation. Studies on mice and humans showed improvements in fat reduction, insulin resistance, and glucose tolerance, suggesting its potential in obesity management.
New insights into how stress affects pancreatic cells and diabetes risk
October 8, 2024 / Pancreatic Cell Stress Diabetes / Type 2 Diabetes / Insulin-producing Cell Failure / Diabetes
Researchers at The Jackson Laboratory found that DNA changes linked to type 2 diabetes affect pancreatic cells’ ability to handle stress. This vulnerability may lead to insulin-producing cell failure under conditions like inflammation, pointing to potential treatment targets.
GLP-1 drugs protect brain health by improving neurovascular function and reducing inflammation
October 7, 2024 / GLP-1 Receptor Agonists / Neurovascular Health / Obesity / Brain Function / Alzheimer’s
GLP-1 receptor agonists, known for managing obesity, also improve brain health by enhancing neurovascular function, reducing inflammation, and protecting against neurodegenerative diseases. These benefits include better brain blood flow, insulin sensitivity, and reduced neuroinflammation.
Cardiovascular
Childhood Obesity
Clinical Trials
Diabetes
Drug Discovery
GLP-1
Insulin
Liver Disease
MASH
Metabolic Disease
Metabolic Syndrome
Obesity
Pancreatic Cancer
Type 2 Diabetes
Weight Gain
Weight Loss