Metabolic impact of dietary glycine supplementation in individuals with severe obesity
October 17, 2025 / Glycine / Obesity / MASLD
Liver Health / Detoxification / Glycine
Metabolism / Amino Acids / Metabolic Disease / Liver
MASLD / 1-Carbon Cycle / Glycine Therapy
Dietary glycine supplementation in individuals with severe obesity improved glycine levels, enhanced detoxification pathways, reduced triglycerides and liver enzymes, and positively influenced markers of metabolic dysfunction-associated liver disease (MASLD), warranting further investigation as a potential therapeutic approach.
Study links obesity-driven fatty acids to dangerous form of breast cancer
October 17, 2025 / Obesity / Breast Cancer / Lipids
Triple-Negative / Cancer / Obesity
Hyperlipidemia / Tumor Growth
Obesity-driven lipids fuel growth of triple-negative breast cancer, with research showing that high-fat diets may worsen outcomes. Lipid-lowering—not just weight loss—is critical to reducing cancer risk in obesity-related breast cancer cases.
Simple hand grip test may reveal your future obesity risk
October 20, 2025 / Handgrip Strength / Obesity Risk / Muscle
Preclinical Obesity / BMI Limitations / Fat
Visceral Fat / Muscle Weakness
Handgrip strength may predict progression from preclinical to clinical obesity more effectively than BMI, offering a simple, functional marker for early obesity risk assessment and prevention strategies, especially as BMI alone often misrepresents true health status.
Skipping breakfast may increase hypertension, high blood sugar risk
October 20, 2025 / Skipping Breakfast / Metabolic Syndrome / Hypertension
High Blood Sugar / Breakfast Impact / Obesity
Heart Disease / Metabolism
A meta-analysis links skipping breakfast to increased risk of metabolic syndrome—particularly high blood pressure, blood sugar, and abdominal obesity—highlighting breakfast’s role in supporting metabolic regulation and preventing cardiovascular and metabolic disease progression.
Interleukin-18 in obesity and obesity-related metabolic diseases
October 17, 2024 / IL-18 / Obesity / Metabolism
Cytokines / Liver Fibrosis / Inflammation
Interleukin-18 / Diabetes
Interleukin-18 (IL-18) plays dual roles in obesity—its deficiency promotes weight gain, while chronic signaling drives liver fibrosis. As IL-18 is elevated in obesity and diabetes, targeting IL-18 pathways offers promising therapeutic potential for metabolic diseases.
Building muscle shown to protect against obesity-related organ damage
October 15, 2025 / Muscle Strength / Obesity Risk / Organ Damage
Handgrip Test / Preclinical Obesity / Mortality
Muscle Mass / Metabolic Health
Building and maintaining muscle strength, particularly measured through handgrip, significantly reduces the risk of obesity-related organ damage and early death, highlighting muscle mass as a protective factor in individuals with excess body fat or preclinical obesity.
Twin Health, Peloton Team Up To Tackle Diabetes, Obesity With AI And Fitness
October 14, 2025 / Twin Health / Peloton / Diabetes
Digital Twin / Obesity Care / AI
Metabolic Health
Twin Health partnered with Peloton to integrate personalized fitness content into its AI-driven Digital Twin platform, enhancing treatment for diabetes, obesity, and prediabetes by combining precision metabolic insights with guided physical activity and wellness practices.
Welldoc Expands AI-Powered Cardiometabolic Platform to Include Chronic Kidney Disease and MASH Support
October 15, 2025 / Welldoc / AI Health / CKD
MASH / Fatty Liver / Obesity
Cardiometabolic Care / Digital Health / Diabetes
GLP-1
Welldoc has expanded its AI-powered cardiometabolic platform to include support for chronic kidney disease (CKD) and MASH, offering personalized, evidence-based digital tools to improve early detection, lifestyle management, and clinical outcomes in these high-risk, obesity-related conditions.
Women with metabolic syndrome face higher risk of gynaecological cancers, finds study
October 17, 2025 / Metabolic Syndrome / Gynecological Cancer / Women
Endometrial Cancer / Obesity Risk / MetS
Ovarian Cancer / Metabolic Health
A systematic review found that women with metabolic syndrome face a significantly higher risk of developing gynecological cancers, including ovarian, endometrial, cervical, vaginal, and vulvar cancers, underscoring the need for early metabolic risk detection and intervention.
Finding the Best Match for MASLD Management
October 20, 2024 / MASLD / Resmetirom / Semaglutide
MASH / Liver Disease / Obesity
Fibrosis / GLP-1 Therapy
New FDA-approved therapies—resmetirom and semaglutide—offer targeted treatment options for MASLD, addressing fibrosis and metabolic dysfunction. Experts recommend individualized, multidisciplinary care integrating pharmacologic and lifestyle strategies to manage this increasingly prevalent liver disease linked to obesity and diabetes.
Novo Nordisk’s Akero Therapeutics Buy Targets Eli Lilly’s Lead
October 15, 2025 / Novo Nordisk / Akero / MASH
EFX / Liver Disease / Obesity
GLP-1 / Oral Wegovy
Novo Nordisk’s $4.7B acquisition of Akero Therapeutics strengthens its position in obesity-related liver disease by advancing efruxifermin (EFX) for MASH, aiming to outpace Eli Lilly in NASH treatments and expand its metabolic disease portfolio beyond GLP-1 therapies.
Nearly 90% of adults are at risk for this condition, but most have never heard of it, survey finds
Nearly 90% of U.S. adults have risk factors for cardiovascular-kidney-metabolic (CKM) syndrome, yet most are unaware. Defined in 2023, CKM highlights the interconnected risks of heart, kidney, and metabolic disease, underscoring the need for integrated, preventive care.
Nearly 90% of adults are at risk for this condition, but most have never heard of it, survey finds
October 20, 2025 / CKM Syndrome / Heart Disease / Kidney Health
Metabolic Syndrome / Obesity Risk
Cardiovascular-kidney-metabolic (CKM) syndrome affects nearly 90% of U.S. adults, yet few are aware. Defined by the AHA in 2023, CKM highlights the interconnected risks of heart, kidney, and metabolic diseases, requiring integrated prevention and holistic treatment approaches.
Comparable Cardiorenal Outcomes Among Three GLP-1 Receptor Agonists in Veterans with Type 2 Diabetes: JAMA
A large retrospective study found semaglutide, liraglutide, and dulaglutide offered comparable kidney and cardiovascular protection in veterans with type 2 diabetes, though mortality risks and some adverse events varied—highlighting the need for head-to-head trials to guide treatment choice.
BMI alone may not be enough to measure cardiometabolic disease risk among adults, researchers find
October 20, 2025 / BMI Limitations / Adiposity / Cardiometabolic Risk
Waist Circumference / Obesity
Researchers at UTHealth Houston found BMI alone underestimates cardiometabolic disease risk. Many adults with “normal” BMI still have excess adiposity, especially abdominal fat, significantly increasing risk for diabetes, hypertension, and heart disease—highlighting the need for waist and fat-specific assessments.
The BMIgap tool to quantify transdiagnostic brain signatures of current and future weight
October 20, 2025 / BMIgap / Brain Imaging / Weight Prediction
Schizophrenia / Depression / Obesity Risk
Psychiatric Disorders / Metabolic Health
The BMIgap tool, derived from brain imaging, quantifies discrepancies between predicted and actual BMI, identifying individuals—especially those with psychiatric conditions—at risk for future weight gain, offering a novel approach to guide early, personalized metabolic interventions.
Reducing sedentary behavior and increasing light physical activity can support metabolic health
October 14, 2025 / Sedentary Behavior / Metabolic Health / Physical Activity
Light Exercise / Fat Burning / Diabetes Prevention
Reducing daily sitting time by just 30 minutes and increasing light activity—like standing or walking—can improve metabolic flexibility and fat utilization, particularly in physically inactive individuals at risk for type 2 diabetes and cardiovascular disease.
Combination of prebiotics and probiotics offer superior anti-inflammatory benefits compared with omega-3 or prebiotics alone
October 16, 2025 / Synbiotic / Inflammation / Gut Health
Kefir / Prebiotic Fiber / Microbiome
Probiotics / Metabolic Health
A University of Nottingham study found that combining kefir-derived probiotics with diverse prebiotic fibers (a synbiotic) significantly reduced systemic inflammation more effectively than omega-3 or prebiotics alone, suggesting enhanced support for immune and metabolic health through microbiome-targeted nutrition.
Air pollution’s hidden cost: Study finds links to metabolic dysfunction and type 2 diabetes
Brown Fat
Air pollution, specifically PM2.5, disrupts brown adipose tissue via epigenetic changes driven by HDAC9 and KDM2B, impairing insulin sensitivity and promoting metabolic dysfunction—linking long-term exposure to increased risk of type 2 diabetes and related conditions.
Study finds hidden blood mutations spark obesity, diabetes and liver disease
UF Health researchers discovered that age-related blood stem cell mutations—known as clonal hematopoiesis—can drive obesity, diabetes, and fatty liver disease, suggesting early blood testing could help predict risk and guide preventive lifestyle or pharmacologic interventions.