4 Foods Doctors Say You Should Be Eating To Prevent Cancers, Metabolic Syndrome And Weight Gain: Berries, More
October 20, 2024 / Cancer-preventing Foods / Fiber-rich / Weight Loss / Metabolic Syndrome Diet Prevention / Antioxidants / Cancer Prevention / Weight Management
Experts recommend cruciferous vegetables, berries, fatty fish, and almonds for their ability to reduce cancer risk, support weight loss, and prevent metabolic syndrome. These foods are rich in fiber, antioxidants, and healthy fats, promoting overall health.
Epigenetic programming of obesity in early life through modulation of the kynurenine pathway
October 18, 2024 / Epigenetics Childhood Obesity / Fetal Development / Metabolic Health / Obesity Epigenetic Programming
Epigenetic changes during fetal development, particularly in the kynurenine pathway, may increase the risk of childhood obesity. Maternal inflammation influences these modifications, potentially affecting metabolic health and obesity risk later in life.
Study finds oral contraceptives may alter glycemic response in women using androgenic pills
October 18, 2024 / Androgenic Oral Contraceptives / Glycemic Response / Insulin Resistance / Birth Control / Women’s Health
The study found that women using androgenic oral contraceptives experienced increased postprandial glucose, insulin, and C-peptide levels, suggesting these pills may impair glucose tolerance and increase insulin resistance during the active phase.
Hysterectomy and Hystero-Oophorectomy Linked to Increased Metabolic Syndrome Risk
October 18, 2024 / Metabolic Syndrome Risk / Cardiovascular Risk / Women’s Health
A study found that hysterectomy, even without ovary removal, increases the risk of developing metabolic syndrome, which is linked to cardiovascular disease. These findings suggest the need for increased screening and preventive measures in women undergoing such surgeries.
New FDA Designations May Jumpstart Gene Therapy Development
October 18, 2024 / FDA / Gene Therapey / Rare Pedidatric Disease / Gene Therapy
The FDA granted Rare Pediatric Disease and Orphan Drug Designations to five investigational gene therapies developed by NCATS and BGTC for rare diseases. These designations provide financial incentives, accelerating gene therapy development for conditions with limited commercial interest.
Altered body fat, metabolic disturbances common in SMA adults
October 18, 2024 / Metabolic Disturbances / Body Composition in SMA / Cardiometabolic Risk / Insulin Resistance
A study found adults with spinal muscular atrophy (SMA), particularly non-ambulatory individuals and those with SMA type 2, experience altered body composition and metabolic disturbances, including insulin resistance and abnormal lipid profiles, increasing their cardiometabolic risk.
Diet may improve brain health in older adults with obesity
October 17, 2024 / Brain Health Diet / Obesity Brain Health / Intermittent Fasting Benefits / Alzheimer’s Insulin Resistance / Healthy Aging Diet
A healthy diet, including intermittent fasting, can improve brain health, cognition, and insulin resistance in older adults with obesity and metabolic issues, though it doesn’t alter Alzheimer’s biomarkers, according to an NIA-led study.
The relationship between leptin-to-adiponectin ratio and HOMA-IR and metabolic syndrome in five African-origin populations
October 17, 2024 / Metabolic Syndrome / Insulin Resistance / Leptin-to-adiponectin ratio
This study examined the relationship between leptin-to-adiponectin ratio, HOMA-IR, and metabolic syndrome in five African-origin populations. Results showed varied associations between these markers and metabolic syndrome across populations, highlighting geographic differences in metabolic health determinants.
As Fiber Intake Goes Up Metabolic Disease Risk Goes Down, According to New Study
October 17, 2024 / Metabolic Syndrome / Metabolic Health / Fiber Benefits / Chronic Disease Prevention
A recent study found that each 1-gram increase in dietary fiber intake reduces the risk of metabolic syndrome by 9%. Higher fiber consumption improves gut health and helps prevent conditions like heart disease, diabetes, and obesity.
Study reveals gender differences in Rett syndrome progression
October 17, 2024 / Gene Regulation Rett Syndrome / Neurodevelopment Disorders
A UC Davis study revealed gender differences in Rett syndrome progression, finding that females experience more gene dysregulation at different stages than males. The study suggests Rett’s severity is linked to disrupted gene regulation and may impact other diseases.
Diabetes, high BMI, previous metformin prescriptions are common in teens with prescriptions for GLP-1 Ras
October 16, 2024 /GLP-1 Ras Adolescents / Diabetes / Adolescent Metformin Prescription / Metabolic Health
Teens prescribed GLP-1 receptor agonists (GLP-1 RAs) are more likely to have type 2 diabetes, high BMI, or previous metformin use. These findings highlight the importance of studying the long-term impacts of GLP-1 RAs in adolescent patients.
Gene therapy might help prevent arthritis, other problems in overweight kids
October 15, 2024 / Gene Therapy / Obesity-related Arthritis Prevention / Childhood Obesity Risks / Inflammation Reduction Obesity
A new gene therapy in mice shows potential to reduce obesity-related health issues, like arthritis, by converting pro-inflammatory omega-6 fatty acids into beneficial omega-3s, improving metabolic health and early arthritis symptoms in overweight children.
OrsoBio Announces Publication of Preclinical Data on Novel Approach for Regulating Metabolic Dysfunction and Reducing Inflammation and Fibrosis
October 15, 2024 / OrsoBio / MetabolicDisease / Liver Health / MASLD/MASH Treatment / Obesity Disorders
OrsoBio’s preclinical data reveals that inhibiting ACMSD increases NAD+ levels, reducing DNA damage, inflammation, and fibrosis in metabolic liver diseases like MASLD/MASH. This approach shows promise for treating obesity-related liver and kidney disorders by improving mitochondrial function.
Scientists identify key protein in the inflammatory pathway driving fatty liver disease
October 15, 2024 / Fatty Liver Disease / MASH Treatment
Researchers identified the Rbpj protein in the Notch signaling pathway as a key regulator of inflammation in MASH. Inhibiting Rbpj reduces inflammatory macrophages and promotes protective monocytes, offering a potential therapeutic target for fatty liver disease treatment.
Combination of Genetic Risk for Gout and Poor Lifestyle Choices Increases Risk for Cardiovascular Disease
October 15, 2024 / Genetic Risk / Metabolic Health Cardiovascular Risk / Polygenic Risk
A study found that individuals with a genetic predisposition to gout, poor lifestyle habits, and poor metabolic health face an increased risk of cardiovascular disease (CVD). However, adopting a healthy lifestyle can reduce this risk by up to 62%.
Is high-speed internet fueling the obesity epidemic?
October 14, 2024 / Obesity / High-speed Internet / Digital Lifestyle / Internet Usage Health Impact
High-speed internet access is associated with increased obesity rates, as shown in an Australian study. Sedentary behavior and physical inactivity, driven by internet usage, mediate this relationship, emphasizing the need for policies promoting physical activity.
Gene therapy that converts omega-6 to omega-3 fatty acids in the body could combat effects of childhood obesity
October 14, 2024 / Childhood Obesity / Gene Therapy / Obesity Arthritis Prevention / Metabolic Health / Inflammatory Fatty Acids Treatment
Researchers developed a gene therapy that converts omega-6 to omega-3 fatty acids, reducing inflammation and obesity-related arthritis in children. This breakthrough could significantly lower the risk of metabolic diseases caused by childhood obesity.
Inventiva announces financing of up to €348 million to advance the NATiV3 Phase 3 MASH study
October 14, 2024 / Inventiva Lanifibranor MASH / Clinical Trial Funding / MASH Treatment
Inventiva secures up to €348 million to advance its Phase 3 NATiV3 trial evaluating lanifibranor for noncirrhotic MASH. The funding will support trial completion, marketing approval, and commercialization preparations for this promising therapy targeting metabolic liver disease.
Weight-loss surgery may lower risk of pancreatic cancer in people with obesity
October 14, 2024 / Weight-Loss Surgery / Pancreatic Cancer / Obesity Pancreatic Cancer Risk / Bariatric Surgery Cancer Prevention / Type 2 Diabetes
A meta-analysis revealed that weight-loss surgery significantly reduces pancreatic cancer risk in people with obesity, particularly those with type 2 diabetes. Surgery lowered cancer risk by 44% in those without diabetes and 79% in those with both conditions.
How gut microbiome and fiber diversity shape chronic disease outcomes
October 13, 2024 / Gut Microbiome Fiber Diversity / Chronic Disease / Fiber Gut Health Obesity / Cardiometabolic Disease
This review highlights how dietary fiber diversity influences gut microbiome composition and its role in reducing chronic diseases like obesity, cancers, and cardiometabolic conditions. Personalized approaches may optimize fiber’s health benefits due to individual gut microbiome differences.