People who exercise have healthier belly fat, new study finds
September 16, 2024 / Belly Fat / Obesity / Metabolic Health / Fat Tissue
A University of Michigan study found that regular exercisers with obesity have healthier belly fat, showing more blood vessels, reduced inflammation, and greater fat storage capacity, which lowers the risk of visceral fat-related diseases like diabetes and heart disease.
Will New Obesity Drugs Make Bariatric Surgery Obsolete?
September 16, 2024 / Obesity Drugs vs Surgery / Bariatric Surgery / Obesity Treatment Innovations / Long-term Obesity Management
At the EASD 2024, experts debated whether new obesity drugs could replace bariatric surgery. While medications offer metabolic benefits, surgery’s long-term efficacy and ability to resolve conditions like type 2 diabetes ensure its continued relevance.
Higher soft drink consumption linked to increased risk of liver disease
September 16, 2024 / Liver Disease / Soft Drinks / Liver Enzymes / Metabolic Health
A study found that higher soft drink consumption is linked to increased liver enzyme levels and a higher risk of nonalcoholic fatty liver disease (NAFLD) in males, with significant associations between soft drink intake and liver health.
Association of different obesity indexes with diabetic kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study
September 16, 2024 / Diabeteic Kidney Disease Predictors / Obesity Disease / Type 2 Diabetes / Kidney Complications
This study found that visceral adiposity index (VAI), lipid accumulation product index (LAPI), and visceral fat area (VFA) were positively associated with diabetic kidney disease (DKD) severity in type 2 diabetes patients, highlighting key obesity-related predictors of DKD risk.
Genotype-driven therapeutics in DEE and metabolic epilepsy: navigating treatment efficacy and drug resistance
September 16, 2024 / Drug-resistant Epilepsy Treatment / Metabolic Epilepsy Therapeutic Strategies
A study on developmental and epileptic encephalopathy (DEE) and metabolic epilepsy (ME) found that genetic variants influence drug resistance. Exome sequencing identified key variants, with ketogenic diets benefiting 80% of drug-resistant DEE patients. Personalized treatments could enhance therapeutic efficacy.
Researchers uncover how brown fat cells increase metabolic activity
September 16, 2024 / Brown Fat Cell Thermogenesis / Metabolic Activity / Metabolic Disease Treatment
Researchers uncovered how brown fat cells increase metabolic activity by reducing “”inhibitory factor-1″” levels in response to cold, allowing thermogenesis instead of ATP production. This discovery may lead to new treatments for metabolic diseases by activating brown fat.
Much hyped AI products like ChatGPT can provide medics with ‘harmful’ advice, study says
September 16, 2024 / AI / Diabetes Management / Metabolic Disorder / AI Guidance
A study found that ChatGPT provides incomplete or incorrect advice on managing diabetes and metabolic disorders, missing key recommendations like weight loss and nutrient guidance. Researchers warn healthcare professionals against relying solely on AI for clinical decisions.
Optimal fasting duration for mice as assessed by metabolic status
September 15, 2024 / Metabolic Research / Animal Welfare / Blood Glucose
This study examined optimal fasting duration in mice fed low- or high-fat diets, revealing that 6-hour fasts maintain metabolic stability without causing significant blood glucose fluctuations. The findings aim to optimize experimental design and animal welfare.
Maternal glucose homeostasis during pregnancy in women with overweight or obesity and offspring metabolic health
September 13, 2024 / Obesity / Maternal Glucose Pregnancy / Offspring Metabolic Health / Gestational Glucose
In women with overweight or obesity, maternal glucose levels during pregnancy—without gestational diabetes—are linked to higher C-peptide concentrations, weight-for-length, and BMI z-scores in offspring at birth, suggesting early impacts on metabolic health.
Using anthropometric parameters to predict insulin resistance among patients without diabetes mellitus
September 13, 2024 / Insulin Resistance Prediction / BMI
This study found that body mass index (BMI), arm circumference, and waist circumference were positively associated with insulin resistance (IR), while thigh circumference was negatively correlated. These anthropometric measures could help predict IR in non-diabetic individuals.
Sagimet Announces Oral Presentation at the 8th Annual MASH Drug Development Summit
September 12, 2024 / MASH Treatment / FASN Inhibitor / Liver Disease
Sagimet Biosciences will present data on denifanstat, a novel FASN inhibitor, at the 8th Annual MASH Drug Development Summit. Denifanstat shows promising anti-fibrotic effects in metabolic dysfunction-associated steatohepatitis (MASH), with positive Phase 2b clinical trial results.
Endurance exercise transforms fat tissue and boosts metabolic health in adults with obesity
September 11, 2024 / Endurance Exercise / Obesity / Metabolic Health / Insulin Resistance / Cardiometabolic Benefits
Long-term endurance exercise enhances fat tissue function in individuals with obesity by increasing capillary density and metabolic activity, improving cardiometabolic health markers like insulin resistance and HDL cholesterol, independent of weight loss.
Brazilian research uncovers how liver nerves regulate glucose production under stress
September 11, 2024 / Metabolic Diseases / Liver Nerves / Glucose Production
A Brazilian study revealed how liver nerves regulate glucose production during stress via the sympathetic nervous system, specifically involving noradrenaline and CREB/CRTC2 proteins. This understanding offers insights into metabolic diseases like diabetes and obesity.
Long-term exercise training has positive effects on adipose tissue in overweight or obesity
September 10, 2024 / Cardiometabolic Health / Long-term Exercise Benefits / Obesity / Metabolic Health
Long-term exercise in adults with overweight or obesity improves abdominal fat tissue structure and biology, contributing to enhanced cardiometabolic health compared to sedentary individuals with similar weight profiles.
High linoleic acid intake during pregnancy may harm fetal growth and raise obesity risk
September 10, 2024 / Linoleic Acid Pregnancy Risks / Fetal Growth / Obesity / Maternal Diet
High maternal intake of linoleic acid (LA) during pregnancy may impair fetal growth, increase inflammation, and raise offspring obesity risk by disrupting essential fatty acid balance and promoting pro-inflammatory compounds. More research is needed to confirm these effects in humans.
Common diabetes drug slows growth of normal cells carrying cancer mutation, finds study
September 10, 2024 / Cancer Prevention / Diabetes Drug Repurposing / Obesity / Cancer Growth
A study found that metformin, a common diabetes drug, slows the growth of precancerous cells with PIK3CA mutations in the esophagus, potentially reducing cancer risk. Metabolic conditions like obesity and diabetes may accelerate these cells’ growth.
FDA Grants 510(k) Clearance to Sonic Incytes’ Velacur® Determined Fat Fraction (VDFF), a breakthrough for patients with MASLD and MASH
September 10, 2024 / Liver Fat Measurement / MASLD / FDA Clearance
The FDA has granted clearance for Sonic Incytes’ Velacur® Determined Fat Fraction (VDFF), a non-invasive tool for measuring liver fat. VDFF offers point-of-care accuracy comparable to MRI, improving the diagnosis and management of MASLD and MASH.
Study reveals how insulin-producing cells work together to respond to metabolic demands
September 10, 2024 / Insulin / Metabolic Demands / Insulin Research
A study in eLife shows how insulin-producing cells (IPCs) in fruit flies work together to respond to metabolic demands. Diverse neuromodulatory inputs help IPCs adapt insulin release, providing insights into metabolic regulation relevant for diabetes research.
A cellular model system for drug development in fatty liver disease
September 9, 2024 / Fatty Liver Disease / MASLD Drug Development / 3D Liver Cell Culture
Researchers at Heidelberg University developed a 3D in vitro model using human liver cells to study fatty liver disease (MASLD) and test drug efficacy. This system offers insights into disease mechanisms and personalized treatments based on sex and ethnicity.