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Impact Overview

Designing & Building Highly Differentiated Products


Top 20 Pharma

Global Lifecycle Management

Two Top 20 global PharmaCo’s in an alliance, had 3rd to market product in its class with blockbuster sales expectations. The launch strategy was not meeting expectations, having little perceived clinical differentiation. Vault Bioventures was engaged to assist the client in developing a more competitive differentiation strategy and lifecycle plan that was inclusive of phase 3 data-generation, phase 4 studies, health economics, and lifecycle indications.

A new focus on unique and untapped pharmacodynamic properties led to a revised brand and lifecycle strategy resulting in 90%+ of the clinicians surveyed indicating they would increase their prescribing behavior ~25%.The impact on within-category prescription patterns was estimated to result in a tripling of the preference share with a potential to increase sales >$350M/year.


Mid-Size Pharma

New Indication

A post-Launch product in US market was performing significantly below forecast. The product was undifferentiated clinically and significantly behind competitors on lifecycle plans and future indications. Additionally, the client had never developed a lifecycle management strategy for the product.

A comprehensive lifecycle evaluation identified two new potential indications. Supporting the client on scientific and market assessment, primary market research (both qual and quant), development of forecast model (and executive presentations for board approval). Client invested $500M+ and successfully achieved 2 new indications, 1 new product, ~3x increase in market share, as well as LOE extension.


Top 20 Pharma

Lifecycle and 5-Year Strategy

Vault’s client had recently launched prescription product in a highly competitive and minimally differentiated product category – in a top five therapy class. Vault was engaged to build a 5-year, U.S. strategic and life cycle plan for this product. Based on a significant gap in available and impactful clinical data, Vault recommended several studies to support product differentiation. Subsequent market research evaluated the updated target product profile and demonstrated increased intent to use among key customer segments.

We conducted a clinical and commercial evaluation of the global opportunity and identified significant opportunities for value creation via further enhancement of the product profile to demonstrate clinical differentiation and appropriate patient segments, analyzed and identified differentiation opportunities that resulted in 3x increase in physician preference for our client. The strategic recommendations gave our client a new perspective needed to secure an additional $20M in funds to support clinical programs and product differentiation.

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