Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases March 9, 2026 / Hyperinsulinaemia / Obesity Pathophysiology / Cardiometabolic Disease / Insulin Resistance / Metabolic Health Chronic basal hyperinsulinaemia may independently drive adiposity and cardiometabolic disease beyond normal postprandial insulin...

Obesity as a catalyst for neurodegeneration February 27, 2026 / Obesity and Neurodegeneration / Chronic Metabolic Overload / Blood–Brain Barrier Dysfunction / Neurovascular Coupling / Cognitive Decline Midlife obesity is increasingly linked to neurodegeneration through brain-wide metabolic, vascular, and neural...

Genetic determinants of BMI, diet, and fitness interact to partially explain anthropometric obesity traits but not the metabolic consequences of obesity in men and women February 20, 2026 / Polygenic Risk Score / Precision Nutrition / Metabolic Syndrome / Obesity...

Oral bacteria may signal metabolic health and even contribute to obesity Distinct oral microbiome signatures in obesity show altered sugar fermentation, increased lactate production, and inflammatory pathways, correlating with triglycerides and metabolic markers, suggesting saliva-based microbial profiling may serve as...

Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells February 9, 2026 / GLP-1 secretion / human jejunal enteroids / obesity and type 2 diabetes / enteroendocrine cell dysfunction / metabolic disease models Human jejunal enteroids...