Obesity can affect metabolic processes and liver function, study finds
February 26, 2024 / Obesity / Liver Function / Metabolism
Researchers say they have found that the biological regulation of metabolic activity was reversed in mice with obesity in a studyTrusted Source published today in the journal iScience.
In non-obese mice, the researchers report that allosteric regulation, the biological process that controls metabolism, was inhibited during feeding and activated when the mice were fasting.
Fish oil in pregnancy linked to child weight gain and metabolic risks
February 25, 2024 / Fish oil / Pregnancy / Weight Gain
A randomized controlled trial published in The American Journal of Clinical Nutrition claims that fish oil supplementation during pregnancy can increase the risk of weight gain and metabolic syndrome in the offspring at the age of ten.
Mice study suggests metabolic diseases may be driven by gut microbiome, loss of ovarian hormones
February 22, 2024 / Mice / Metabolic Diseases / Weight Gain / Liver
The gut microbiome interacts with the loss of female sex hormones to exacerbate metabolic disease, including weight gain, fat in the liver and the expression of genes linked with inflammation, researchers found in a new rodent study.
Obesity, metabolic syndrome heighten odds for asthma
February 24, 2024 / Obesity / Metabolic Syndrome / Athma
Obesity and metabolic syndrome each increased the odds for asthma in adults, with even higher odds found with both factors, according to data presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting.
Prevalence of Adolescents Meeting Criteria for Metabolic and Bariatric Surgery
February 27, 2024 / Obesity / Bariatric Surgery
The American Academy of Pediatrics endorses metabolic and bariatric surgery (MBS) as a safe and effective treatment of severe obesity in children with class 3 obesity or with class 2 obesity and qualifying comorbidities. The study objective was to determine eligibility and characteristics of adolescents who qualify for MBS based on American Academy of Pediatrics guidelines.
Health officials announce development of Cardio-Kidney-Metabolic syndrome
February 25, 2024 / San Diego / Cardio-Kidney-Metabolic Syndrome / Heart Disease
Health officials are redefining heart disease — announcing the development of Cardio-Kidney-Metabolic syndrome, or CKM. One in three people are at risk of developing it. It’s not a new disease, but a new way of thinking about how existing conditions affect one another and how we should be treating them.
9amHealth raises $9.5M extension for virtual metabolic care
February 20, 2024 / 9amHealth / Metabolic
9am Health, a virtual provider for cardio-metabolic health, raised a $9.5 million Series A extension.
Obesity disrupts normal liver function in mice
February 26, 2024 / Obesity / Liver / New Study
Your liver plays a vital role in your metabolism, the biological process which converts food into energy. We know that being overweight can negatively affect metabolic activity, but not exactly how. To better understand this, researchers compared the livers of mice which were a typical weight with mice which were obese. They were surprised to find that biological regulation of metabolic activity, after a period of feasting and fasting, was reversed between them.
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans
February 24, 2024 / rRNA / Metabolic Diesease
Ribosome biogenesis is initiated by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal RNA (pre-rRNA). Pol I activity was previously linked to longevity, but the underlying mechanisms were not studied beyond effects on nucleolar structure and protein translation. Here we use multi-omics and functional tests to show that curtailment of Pol I activity remodels the lipidome and preserves mitochondrial function to promote longevity in Caenorhabditis elegans. Reduced pre-rRNA synthesis improves energy homeostasis and metabolic plasticity also in human primary cells.
Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages
February 27, 2024 / PHGDH / Cancer Treatment / Immune System
A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology, has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus on tumor growth.
Proteogenomics of metabolic disease
February 23, 2024 / Metabolic Disease / Diabetes / Obesity
In this video, Olink® presents proteogenomics of metabolic diseases, an expert-led discussion on the use of proteogenomics in uncovering molecular mechanisms underlying metabolic diseases such as diabetes and obesity.
Primary Cicatricial Alopecia Linked to Metabolic and Endocrine Comorbidities
February 27, 2024 / Metabolic Disorders / Endocrine Disorders
Patients with primary cicatricial alopecia (PCA) are more likely to develop metabolic and endocrine comorbidities compared with those with noncicatricial alopecia (NCA), according to study findings published in The Journal of Dermatology.
Singapore-based Women’s Health Platform Ease Healthcare Launches Metabolic Health and Weight Loss Offering
February 21, 2024 / Women’s Health / Metabolic Disease / Weight Loss
Elevate, the latest digital health platform launched by Ease Healthcare, a leading women’s health ecosystem in Asia, aims to address metabolic health and weight management issues specifically tailored for women. The platform integrates various elements including modern medical practices, expert guidance, community support, and digital tools to provide women with effective solutions for sustainable weight loss and improved metabolic health.
Survodutide Phase II trial shows 83% of adults treated achieved groundbreaking results in liver disease due to MASH, with significant improvements in fibrosis
February 26, 2024 / Clinical Trials / Liver Disease / Metabolic Disease / Obesity / Boehringer Ingelheim
The trial met its primary endpoint with survodutide reaching a biopsy-proven improvement in MASH after 48 weeks, without worsening of fibrosis stages F1, F2 and F3 (mild to moderate or advanced scarring).2 Survodutide also met all secondary endpoints, including a statistically significant improvement in liver fibrosis.2 Full data will be presented in the coming months.
NIH study offers new clues into the causes of post-infectious ME/CFS
February 21, 2024 / NIH / Clinical Study / Chronic Disease
In a detailed clinical study, researchers at the National Institutes of Health have found differences in the brains and immune systems of people with post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS). They also found distinct differences between men and women with the disease. The findings were published in Nature Communications.
FSD Pharma begins trial for alcohol metabolism supplement
February 26, 2024 / Alcohol Metabolism / New Study
FSD Pharma Inc., a biopharmaceutical company, announced Monday that its subsidiary, HUGE Biopharma Australia Pty Ltd., has commenced a clinical trial to assess the safety and efficacy of its dietary supplement, unbuzzd™, in healthy volunteers experiencing alcohol intoxication.
Scientists Develop Simple and Cost-Effective Early Diabetes Test
February 21, 2024 / Diabetes / Nerve Damage
An international team of researchers headed by Associate Professor Dr. Johannes Dietrich from the Department of Medicine I of Ruhr University Bochum at St. Josef Hospital in Bochum, Germany, has shown that a mathematical calculation based on just two values taken from a blood sample enables the reliable and inexpensive diagnosis of diabetes at an early stage. The researchers recently published their findings in the Journal of Diabetes.
Canagliflozin Improves Diabetic Kidney Disease By Inducing Fasting-Like And Aestivation-Like Metabolic Patterns: Study
February 21, 2024 / Diabetes / Diabetic Kidney Disease Canagliflozin
China: Canagliflozin (CANA) regulates metabolic reprogramming in diabetic kidney disease (DKD) by inducing fasting-like and aestivation-like metabolic patterns, a recent study published in Diabetologia has shown. The study found that canagliflozin ameliorates diabetic kidney disease by inducing fasting-like and aestivation-like metabolic patterns.
Breakthrough Study by Fred Guengerich’s Lab Sheds Light on Cholesterol Biosynthesis Enzyme P450 51
February 27, 2024 / New Study / Cholesterol Biosynthesis
The laboratory led by Fred Guengerich has recently made a significant breakthrough in understanding the cytochrome P450 51 enzyme, crucial for cholesterol biosynthesis, marking a major advancement in biochemical research. This discovery, outlined in a paper published in Angewandte Chemie in January 2024, provides new insights into the metabolic processes involving sterols and opens up potential pathways for developing targeted treatments against various pathogens. Biochemistry graduate student Kevin McCarty played a pivotal role in this research, focusing on the enzyme’s mechanism in metabolizing lanosterol.
Pesticide Exposure Linked to Obesity, Type 2 Diabetes, and Metabolic Disease in Seniors
February 27, 2024 / Pesticides / Obesity / Type 2 Diabetes / Metabolic Disease
Popular culture and official policy continue to ignore a blatant source of the rise in obesity: chemical exposures, including pesticides. A study, “Associations of chronic exposure to a mixture of pesticides and type 2 diabetes mellitus in a Chinese elderly population,” contributes to the now-massive trove of evidence linking pesticides to diseases and shows that by the time people reach retirement age they are suffering from a heavy burden of contamination that raises their risk of complex disease.
Unveiling metabolic markers of Candida albicans infection
February 27, 2024 / Canida Albicans Infection / Women’s Health
Metabolites can be used as indicators of Candida albicans infection, according to a recent study published in Microorganisms.
Understanding obesity’s effects on liver metabolism
February 26, 2024 / Obesity / Liver / Metabolism
The World Obesity Federation (WOF) estimates that by 2035, over 4 billion people will be overweight or living with obesity. This may lead to a rise in obesity-related health conditions, such as heart disease, nonalcoholic fatty liver disease and Type 2 diabetes. Identifying the causes and effects of obesity, which is now understood to be a complex disease, is key for physicians looking to provide support and help people stay healthy.
Association between remnant cholesterol and insulin resistance levels in patients with metabolic-associated fatty liver disease
February 26, 2024 / NAFLD / Chronic Liver Conditions / Insulin Resistance
Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition with significant implications for patient prognosis, healthcare costs, and public health. The recent shift in nomenclature to metabolic dysfunction-associated fatty liver disease (MAFLD) underscores its close ties with metabolic abnormalities. MAFLD is diagnosed based on the presence of hepatic steatosis along with metabolic disorders like obesity, diabetes, or metabolic dysregulation in lean individuals, offering a broader diagnostic framework compared to NAFLD.
Machine learning model to determine associations between metabolic syndrome and lactation
February 22, 2024 / Machine Learning / Metabolic Syndrome / Women’s Health / Obesity
Metabolic syndrome, which includes hypertension, dyslipidemia, insulin resistance, and central obesity, is associated with type 2 diabetes and cardiovascular disease. Researchers aim to lower this risk, especially during pregnancy-related events like delivery and nursing.
Ursids evolved dietary diversity without major alterations in metabolic rates
February 27, 2024 / Ursids / Metabolic Rates
The diets of the eight species of ursids range from carnivory (e.g., polar bears, Ursus maritimus) to insectivory (e.g., sloth bears, Melursus ursinus), omnivory (e.g., brown bears, U. arctos), and herbivory (e.g., giant pandas, Ailuropoda melanoleuca). Dietary energy availability ranges from the high-fat, highly digestible, calorically dense diet of polar bears (~ 6.4 kcal digestible energy/g fresh weight) to the high-fiber, poorly digestible, calorically restricted diet (~ 0.7) of giant pandas. Thus, ursids provide the opportunity to examine the extent to which dietary energy drives evolution of energy metabolism in a closely related group of animals.