Gut bacteria play a pivotal role in obesity’s impact on body fat metabolism
April 11, 2024 / Obesity / Metabolic Health / Metabolism / Gut Microbiota
Research indicates that gut bacteria significantly influence obesity by affecting mitochondrial function in adipose tissue, highlighting potential therapeutic targets for metabolic health improvement.
Targeting liver and adipose tissue in obese mice: Effects of a N-acylethanolamine mixture on insulin resistance and adipocyte reprogramming
April 3, 2024 / Obesity / Liver / Insulin Resistance / Metabolic Therapy
An olive oil-derived N-acylethanolamine mixture, OLALIAMID®, effectively combats insulin resistance and reprograms adipocytes in obese mice by enhancing liver and adipose tissue function and reducing inflammation.
Obstructive sleep apnea without obesity: the beginning of a journey to “NOOSA”?
April 12, 2024 / Sleep Apnea / Metabolic Syndrome / Cardiovascular Risk / Obesity
Obstructive sleep apnea (OSA) without obesity, termed “”NOOSA,”” poses significant cardiovascular risks due to its association with metabolic syndrome (MetS) factors, challenging detection and management, and highlighting the need for tailored interventions.
Childhood sedentariness causes excessive insulin, raising the risk of type 2 diabetes
April 9, 2024 / Diabetes / Insulin Resistance / Type 2 Diabetes
Childhood sedentariness significantly increases insulin levels and risk of type 2 diabetes; however, light physical activity (LPA) can effectively reduce these risks, according to a study utilizing long-term data from the University of Bristol.
Novo Nordisk’s Dominance In Obesity & Diabetes Drug Market Backed by Strong Pipeline: Analyst Gives Outperform Rating
April 12, 2024 / Novo Nordisk / Obesity / Drug Market / Clinical Trials / Semaglutide Treatment
Novo Nordisk strengthens its market position in obesity and diabetes care with an expanding pipeline including CagriSema and semaglutide, earning an ‘Outperform’ rating from BMO Capital Markets due to promising clinical trials and strategic investments.
Leveraging dairy to boost metabolic health and weight control
April 15, 2024 /Weight Loss / Dairy Products / Metabolism
Studies indicate that high-protein dairy products like Greek yogurt and cottage cheese can enhance satiety and reduce caloric intake, while calcium in dairy assists in regulating fat metabolism and supporting weight loss.
5 Promising MASH Therapies That Could Follow Madrigal’s Rezdiffra
April 15, 2024 / MASH / IONIS / Metabolic Liver Disease
Rezdiffra marks a pivotal advancement in treating metabolic dysfunction-associated steatohepatitis (MASH), but further innovations are necessary as it benefits only a quarter of patients. New therapies, including Ionis’s ION224 and Altimmune’s Pemvidutide, show promise in improving MASH treatment outcomes.
FDA approves novel treatment for liver disease
April 9, 2024 / FDA Approval / Liver Disease / MASH
The FDA has approved Rezdiffra, a novel drug by Madrigal Pharmaceuticals for treating metabolic dysfunction-associated steatohepatitis (MASH), providing the first pharmacological option to address liver fat, inflammation, and scarring in affected patients.
First ever MASH drug primed for big impact in USA
April 4, 2024 / FDA Approval / Healthcare / MASH
Rezdiffra, the first FDA-approved drug for metabolic dysfunction-associated steatohepatitis (MASH) by Madrigal Pharmaceuticals, is expected to be widely adopted in the USA with potential annual revenues surpassing $3.5 billion.
Study identifies novel mechanism of glucose sensing by adipocytes in regulating thermogenesis and energy metabolism
April 9, 2024 / Metabolism / Glucose
A study led by Prof. Li Yu and Prof. Xu Yong revealed a novel glucose sensing mechanism in adipocytes, where glucose enhances thermogenesis via CBP/p300-mediated acetylation of CREBZF, impacting energy balance in adipose tissue.
Bariatric Surgery and Its Metabolic Echo Effect on Serum Uric Acid Levels
April 12, 2024 / Metablic Health / Bariatric Surgery / Obesity
Research demonstrates that bariatric surgery significantly reduces serum uric acid levels, offering metabolic benefits beyond weight loss by enhancing renal function, insulin sensitivity, and reducing inflammation, thereby lowering the risk of gout and related diseases.
Organovo Holdings reports progress in Phase 2 MASH treatment study
April 15, 2024 / Clinical Trial / Liver Diease / Metabolic Health / Liver Fat Reduction
Organovo Holdings reported successful Phase 2 results for FXR314 in treating metabolic function-associated steatohepatitis (MASH), showing significant liver fat reduction and improved liver function without typical FXR agonist side effects.
Study reveals key gut microbiome differences in prediabetic patients
April 11, 2024 / Prediabetes / Insulin / Diet Impact
A study revealed that prediabetic patients have significantly altered gut microbiota compared to healthy individuals, with implications for insulin resistance and metabolic pathways. Diet modifications could potentially stabilize these changes and prevent diabetes progression.
New treatment provides hope for people with fatty liver
April 10, 2024 / Fatty Liver Treatment / Weight Loss / Liver Health / Obesity
A new treatment offers hope for individuals with fatty liver disease, a condition exacerbated by obesity and potentially increased alcohol intake during the pandemic. Early detection and modest weight loss can significantly improve liver health.
Liver tumor, watch out for metabolism. Obesity and insulin resistance are a lethal mix
April 12, 2024 / Metabolic Syndrome / Liver Cancer / Weight Loss / Insulin Resistance
Obesity and insulin resistance significantly heighten the risk of liver cancer, particularly among those with metabolic syndrome. Weight loss, new medications, and bariatric surgery are highlighted as effective measures to reduce this risk, according to the XXX National Congress of Digestive Diseases.
How Insulin Resistance Impacts Weight
April 9, 2024 / Insulin Resistance / Weight Gain / Obesity / In
Insulin resistance complicates weight management by causing high blood sugar levels, increased insulin production, and altered fat storage, which promote obesity and associated diseases. Effective management involves lifestyle changes, exercise, and possibly medication.
A new, viral study linked intermittent fasting to cardiac death — but don’t worry just yet
April 15, 2024 / Metabolic Health / Heart Health / Dietary Patterns / Cardiovascular Risk
A recent study linked intermittent fasting, specifically an 8-hour eating window, to a 91% higher risk of cardiovascular death. Despite its potential short-term benefits, long-term effects remain unclear, emphasizing the need for cautious dietary recommendations.
Experts urge to promote healthy movement behaviors in children under five in Europe
April 9, 2024 / WHO / SUNRISE / Obesity
The SUNRISE European Study Group is calling for urgent actions across Europe to enforce WHO guidelines on physical activity, screen time, and sleep for children under five, aiming to mitigate the childhood obesity pandemic and improve long-term health outcomes.
Neurotech startup Neurovalens gets FDA clearance for noninvasive anxiety treatment
April 9, 2024 / Anxiety / Mental Health / FDA / Medical Devices
Neurovalens, a Belfast-based neurotech startup, received FDA clearance for its noninvasive devices designed to treat generalized anxiety disorder and insomnia through electrical brain stimulation, with more devices, including one for obesity, in development.
This weight-loss ETF has performed well in its first five months. How does it compare with cheaper alternatives?
April 10, 2024 / Obesity / Cardiometabolic / Weight Loss / Healthcare
The Tema Obesity & Cardiometabolic ETF (HRTS), focused on obesity and weight-loss drug investments, performed well in its initial months, showing a 24.2% return since its November launch, despite higher expenses compared to broader healthcare ETFs.
Research uncovers differences between the sexes in sleep, circadian rhythms and metabolism
April 10, 2024 / Metabolic Health / Sleep Disorders
Research shows significant sex-based differences in sleep, circadian rhythms, and metabolism, affecting how conditions like insomnia, restless legs syndrome, and sleep apnea are diagnosed and treated. Women experience more sleep-related disturbances and metabolic changes compared to men.
How to Reverse Insulin Resistance
April 8, 2024 / Insulin Resistance / Type 2 Diabetes / Diet
Gerald I. Shulman of Yale highlights insulin resistance as a global health threat linked to several diseases including type 2 diabetes and heart disease. Research shows reversing insulin resistance through diet, exercise, and medication can significantly improve health.
The association between body mass index and osteoporosis in a Taiwanese population: a cross-sectional and longitudinal study
April 12, 2024 / BMI / Osteoporosis / Taiwan Biobank Study / Weight Loss / Bone Health
A study utilizing the Taiwan Biobank data analyzed the relationship between body mass index (BMI) and osteoporosis, finding underweight individuals had a significantly higher risk of developing osteoporosis compared to those with normal weight.
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting
April 19, 2024 / Metabolic Health / Cystic Fibrosis
Fluorofolin, a novel dihydrofolate reductase inhibitor, effectively targets Pseudomonas aeruginosa, a major cause of hospital infections, by exploiting its unique inability to scavenge thymine, offering potential as a narrow-spectrum antibiotic.
Two decades of data confirm Mediterranean diet cuts hypertension risk
April 15, 2024 / Mediterranean Diet / Hypertension
The 20-year ATTICA study confirms that consistent adherence to the Mediterranean diet significantly reduces hypertension risk, emphasizing its importance in cardiovascular health management and prevention strategies.