Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases March 9, 2026 / Hyperinsulinaemia / Obesity Pathophysiology / Cardiometabolic Disease / Insulin Resistance / Metabolic Health Chronic basal hyperinsulinaemia may independently drive adiposity and cardiometabolic disease beyond normal postprandial insulin...

Obesity as a catalyst for neurodegeneration February 27, 2026 / Obesity and Neurodegeneration / Chronic Metabolic Overload / Blood–Brain Barrier Dysfunction / Neurovascular Coupling / Cognitive Decline Midlife obesity is increasingly linked to neurodegeneration through brain-wide metabolic, vascular, and neural...

Genetic determinants of BMI, diet, and fitness interact to partially explain anthropometric obesity traits but not the metabolic consequences of obesity in men and women February 20, 2026 / Polygenic Risk Score / Precision Nutrition / Metabolic Syndrome / Obesity...

Oral bacteria may signal metabolic health and even contribute to obesity Distinct oral microbiome signatures in obesity show altered sugar fermentation, increased lactate production, and inflammatory pathways, correlating with triglycerides and metabolic markers, suggesting saliva-based microbial profiling may serve as...

Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells February 9, 2026 / GLP-1 secretion / human jejunal enteroids / obesity and type 2 diabetes / enteroendocrine cell dysfunction / metabolic disease models Human jejunal enteroids...

Muscle mass as a resilence factor for endothelial health in obesity February  2, 2026 / obesity / muscle mass / endothelial health / cardiovascular risk / body composition Skeletal muscle mass may serve as a protective resilience factor against endothelial...

Viking Therapeutics, Inc. (VKTX) Advances Obesity Drug Development and Expands Metabolic Disease Pipeline January 26, 2026 / obesity-treatment / GLP-1-agonist / weight-loss-drug / metabolic-disease-therapy / phase-3-trial Viking Therapeutics’ obesity drug VK2735 achieved 14.7% weight loss in Phase 2 trials without...

What Is ‘Metabolic Health,’ and Why Does It Matter? January 16, 2026 / metabolic health definition / obesity insulin resistance / cardiovascular disease risk / GLP-1 obesity treatment / metabolic syndrome prevention Metabolic health refers to the absence of metabolic...

Obesity meta-analysis provides important steer for next-gen drugs January 8, 2026 / Obesity treatment / Weight regain / Drug adherence / Behavioral weight loss / Obesity drug development Scientists have created safer mitochondrial-targeting compounds that increase cellular calorie burning without...

Scientists find a safer way to make cells burn more calories January 5, 2026 / mitochondrial calorie burning / obesity treatment research / weight loss compounds / cellular metabolism boosters / safe fat burning Scientists have created safer mitochondrial-targeting compounds...