Follicular metabolic alterations are associated with obesity in mares and can be mitigated by dietary supplementation
March 30, 2024 / Obesity / Metabolic / Cellular Lipid / Diet
We hypothesized that obesity in the mare promotes follicular lipid accumulation and altered mitochondrial function of oocytes and granulosa cells, potentially contributing to impaired fertility in this population.
From Sugar Spikes to Pressure Peaks: Navigating the World of Diabetes, Hypertension, Obesity, and Kidney Health
March 30, 2024 / Diabetes / Hypertension / Obesity / Kidney Disease
Diabetes, hypertension, obesity, and chronic kidney disease (CKD) are major public health challenges globally, contributing significantly to morbidity and mortality. The co-occurrence and interplay among these conditions exacerbate health outcomes, highlighting the need for an integrated understanding and approach to management.
Researchers discover unexpected factor contributing to obesity spike: ‘The number of obese people worldwide has nearly tripled’
March 31, 2024 / Obesity / Researchers
A study published in the journal Environmental Science & Technology found over 55,000 types of chemicals present in common plastic products, and only 11 of those compounds were able to be identified, as detailed by Earth Day.
New Research Indicates That Popular Diabetes Drug Could Impact Brain Development During Pregnancy
March 31, 2024 / Diabetes / Women’s Health / Pregnancy
As cases of gestational diabetes and metabolic disorders increase during pregnancy, the prescription of metformin has become more common. Despite understanding that this oral antidiabetic medication can pass through the placental barrier, its effects on a child’s brain development remain largely unclear.
Association of anthropometric measures with all-cause and cause-specific mortality in US adults: revisiting the obesity paradox
April 1, 2024 / Obesity / Metabolic Health
Previous studies have shown that the obesity paradox exists in a variety of clinical settings, whereby obese individuals have lower mortality than their normal-weight counterparts. It remains unclear whether the association between obesity and mortality risk varies by anthropometric measures.
Viking reports positive data from Phase I oral obesity treatment trial
March 27, 2024 / Viking Therapeutics / Clinical Trial / Metabolic Disorders / Obesity
Viking Therapeutics has reported positive data from its Phase I multiple ascending dose (MAD) clinical trial of VK2735, an oral tablet under investigation for the treatment of metabolic disorders, such as obesity.
Ketogenic Diet Shows Promise In Treating Serious Mental Illness, Improving Metabolic Health
April 1, 2024 / Ketogenic Diet / Metabolic Health / Mental Health
In a pilot study, researchers from Stanford Medicine have discovered that a ketogenic diet can not only improve metabolic health in patients with serious mental illnesses like schizophrenia or bipolar disorder but also alleviate their psychiatric symptoms.
Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID
March 30, 2024 / Metabolic Health / RNA / COVID
SARS‐CoV‐2, the etiological agent of COVID-19, is devoid of any metabolic capacity; therefore, it is critical for the viral pathogen to hijack host cellular metabolic machinery for its replication and propagation. This single-stranded RNA virus with a 29.9 kb genome encodes 14 open reading frames (ORFs) and initiates a plethora of virus–host protein–protein interactions in the human body.
Impact of NMDA receptors block versus GABA-A receptors modulation on synaptic plasticity and brain electrical activity in metabolic syndrome
March 30, 2024 / NMDA / Metabolic Syndrome
Metabolic syndrome (MetS) is a common disorder associated with disturbed neurotransmitter homeostasis. Memantine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, was first used in Alzheimer’s disease. Allopregnanolone (Allo), a potent positive allosteric modulator of the Gamma-Amino-Butyric Acid (GABA)-A receptors, decreases in neurodegenerative diseases.
Korean drug for metabolism-related steatohepatitis gets FDA’s fast-track designation
March 28, 2024 / Metabolism / MASH / FDA
D&D Pharmatech said Thursday that DD01, an injectable treatment for metabolic-associated steatohepatitis (MASH) being developed by the company, has received fast-track designation from the U.S. Food and Drug Administration. This is the second MASH treatment developed by a Korean company to receive the FDA’s fast-track designation.
Mechanism of muscle atrophy in a normal-weight rat model of type 2 diabetes established by using a soft-pellet diet
April 1, 2024 / Type 2 Diabetes / Weight / Obesity
Dietary factors such as food texture affect feeding behavior and energy metabolism, potentially causing obesity and type 2 diabetes. We previously found that rats fed soft pellets (SPs) were neither hyperphagic nor overweight but demonstrated glucose intolerance, insulin resistance, and hyperplasia of pancreatic β-cells.
In Type 1 Diabetes, Pancreas Size May Predict Disease Progression
April 1, 2024 / Type 1 Diabetes / Pancreas
The size of the pancreas may be a marker for the risk of disease progression in patients with type 1 diabetes, finds a new study published in Diabetes Care, the journal of the American Diabetes Association.
Experts Aim to Use Brown Fat to Burn Fat More Effectively
March 29, 2024 / Cardiovascular Disease / Cancer / Diabetes
Current findings on this topic were presented at the 67th German Congress of Endocrinology. Some statistics highlighted the need. Approximately 53% of the German population (almost 47% of women and 60% of men) are overweight (including obesity). Obesity is present in 19% of adults. The condition not only results in a shorter life expectancy but also increases the risk for cancer, diabetes, and cardiovascular diseases.
Study finds changing trends in arterial disease risk among diabetics
March 28, 2024 / Diabetes / Heart Disease / Obesity
There has been a redistribution in the risk of arterial disease in type 1 and 2 diabetes. The risks of heart attack and stroke have decreased significantly, while complications in more peripheral vessels have increased in relative importance, according to studies at the University of Gothenburg.
Research identifies optimal body weight to reduce cardiovascular risk in diabetes patients
March 30, 2024 / Weight / Cardiovascular Disease / Diabetes / Obesity
New research being presented at this year’s European Congress on Obesity (ECO) in Venice, Italy (12-15 May), identifies the optimum body weight range for adults with type 2 diabetes to minimize their risk of dying from any cardiovascular disease, including heart failure, heart disease, stroke, and chronic kidney disease.
An avocado a day may improve diet quality, researchers suggest
March 30, 2024 / Diet / Cardiometabolic Disease
In the United States, many adults have poor diet quality and do not meet key dietary recommendations provided by the Dietary Guidelines for Americans
Early understanding of diabetes risk could help in better disease management
March 28, 2024 / Disease Management / Diabetes
With diabetes increasing at an alarming rate in the United States, Diabetes Alert Day® is meant to be a one-day “wake-up call” to the seriousness of diabetes and the importance of understanding your risk. The sooner you know your risk, the sooner you can take steps to prevent or even learn to manage the disease. Just ask 35 year old Crystal Gonzalez who says she knew something wasn’t quite right when she felt thirsty all the time.
Study suggests earlier puberty onset may affect adult cardiometabolic health
March 27, 2024 / Cardiometabolic Health / New Study
Experiencing puberty earlier, compared to same-age peers, may be one of the mechanisms through which childhood risk factors influence adult cardiometabolic health issues, according to a study published March 27, 2024 in the open-access journal PLOS ONE by Maria Bleil from the University of Washington and colleagues.
PTC Announces Submission of Sepiapterin MAA for Treatment of PKU to EMA
March 28, 2024 / PTC Therapeutics / PKU / EMA
PTC Therapeutics, Inc. (NASDAQ: PTCT) announced today the submission of the sepiapterin MAA to the European Medicines Agency. The MAA submission is for the treatment of pediatric and adult patients with PKU, including the full spectrum of disease subtypes.
FDA extends review period for govorestat to treat classic galactosemia
March 29, 2024 / FDA / Applied Therapeutics
The FDA review process for govorestat (AT-007; Applied Therapeutics), an investigational novel Aldose Reductase Inhibitor being developed for the treatment of classic galactosemia, has been extended by 3 months and has a new Prescription Drug User Fee Act (PDUFA) date of November 28, 2024.
Prevalence of common autosomal recessive mutation carriers in women in the Southern Vietnam following the application of expanded carrier screening
March 29, 2024 / Women’s Health / Metabolic Health
The common autosomal recessive (AR) mutation carrier is still unknown in Vietnam. This study aims to identify the most common AR gene mutation carriers in women of reproductive age to build a Vietnamese-specific carrier screening panel for AR and X-linked disorders in the preconception and prenatal healthcare program.
Synergistic interaction between hyperlipidemia and obesity as a risk factor for stress urinary incontinence in Americans
March 27, 2024 / Obesity / Urinary Incontinence
Urinary incontinence is a common disease among middle-aged and elderly women, which not only affects the physical and mental health of patients, but also brings a great medical burden to society. Obesity is a known risk factor for urinary incontinence and is the most common secondary cause of hyperlipidemia. Most obese patients also suffer from hyperlipidemia in the clinic.
Untargeted metabolomics-based network pharmacology reveals fermented brown rice towards anti-obesity efficacy
March 30, 2024 / Obesity / Metabolic Health
There is a substantial rise in the global incidence of obesity. Brown rice contains metabolic substances that can help minimize the prevalence of obesity. This study evaluated nine brown rice varieties using probiotic fermentation using Pediococcus acidilacti MNL5 to enhance bioactive metabolites and their efficacy.
Raman spectroscopic analysis for osteoporosis identification in humans with hip fractures
March 29, 2024 / Osteoporosis / Metabolic Health
Osteoporosis is a significant health concern. While multiple techniques have been utilized to diagnose this condition, certain limitations still persist. Raman spectroscopy has shown promise in predicting bone strength in animal models, but its application to humans requires further investigation.