Akero’s New MASH Drug Data: Longer Treatment Leads to More Liver Benefit
March 4, 2024 / MASH / Drug Development / Liver Disease
Akero Therapeutics’ preliminary Phase 2b data show that treatment with its MASH drug, efruxifermin, continued to distance itself from a placebo measured at nearly two years of treatment. The latest Akero data build on six-month results reported in 2022.
Cardiometabolic diseases are most prevalent in rural areas
March 4, 2024 / Cardiometabolic Disease / Metabolic Health
Sara del Olmo Romero One of the participants in the PhD program in Clinical Medicine and Public Health at the University of Granada (UGR), has conducted a study in which he analyzed Effects of loneliness and social isolation About that cardiometabolic risk In this rural setting. The findings show that metabolic syndrome got it too much current are in these populations and in these areas Levels of loneliness and isolation are very high.
The liver and its vital connection to our overall health
March 4, 2024 / Liver / Diabetes / Heart Disease / Chronic Kidney Disease
The above-mentioned diseases all belong to the cardiovascular, renal and metabolic (CRM) system. With up to 20 million deaths annually, CRM diseases are the number one cause of death in the world today. It’s a group of diseases that are all interconnected, co-exist and can amplify one another. For people affected, this means serious health problems that can worsen over time, resulting in a significant burden on lives. It’s therefore unsurprising that people often live with not just one, but several of these conditions.
7 Serious Long-Term Health Risks Of Babies Born To Obese Mothers: Autism, Diabetes, CVD And More
March 5, 2024 / Women’s Health / Obesity
Obesity, a global health concern, extends its ramifications beyond the individual, especially impacting the health of newborns born to obese mothers. While the immediate risks are well-documented, the long-term health implications on these infants deserve equal attention.
NDUFS4 regulates cristae remodeling in diabetic kidney disease
March 4, 2024 / Kidney Disease / Diabetes
The mitochondrial electron transport chain (ETC) is a highly adaptive process to meet metabolic demands of the cell, and its dysregulation has been associated with diverse clinical pathologies. However, the role and nature of impaired ETC in kidney diseases remains poorly understood.
Controlling brown adipose tissue size through EPAC1
March 4, 2024 / Metabolic Health
A new study by Reverte-Salisa and colleagues identifies a molecular mechanism through which the cAMP-mediating protein EPAC1 controls the size of brown and beige adipose tissue. This finding opens the door for the development of pharmacological interventions to prevent the decline of brown adipose tissue in obesity and ageing, and thereby improve metabolic health.
Prevalence of Metabolic Syndrome and Its Risk Factors Influence on Microvascular Complications in Patients With Type 1 and Type 2 Diabetes Mellitus
March 1, 2024 / Metabolic Syndrome / Diabetes
Diabetes mellitus (DM) long-term macrovascular and microvascular complications pose significant health risks and increase mortality. In DM patients, metabolic syndrome (MetSy) either precedes or coexists with the condition. Central obesity, poor glycemic control, hypertension, elevated triglycerides (TG), and low high-density lipoproteins (HDL-C) are the components of MetSy.
Revolutionizing Heart Disease: Introducing Cardio-Kidney-Metabolic Syndrome and Its Impact
March 4, 2024 / Heart Disease / Cardio-Kidney-Metabolic Syndrome / San Diego
San Diego, California, is at the forefront of a significant shift in how health professionals understand and treat interrelated health conditions. Dr. J. Thomas Heywood, a leading Advanced Heart Failure Specialist at Scripps Clinic, has shared insights into Cardio-Kidney-Metabolic (CKM) syndrome, a holistic approach to addressing the interconnectedness of heart disease, kidney dysfunction, and metabolic disorders. This paradigm shift not only illuminates the complexity of these conditions but also underscores a crucial call to action for a more integrated treatment strategy.
Experts explain how diabetes increases risks of triple-negative breast cancer
March 3, 2024 / Breast Cancer / Diabetes
These views were shared by Dr Lubna Saleem, consultant medical oncologist and assistant professor at the Cancer Foundation Hospital, at a seminar titled ‘Diabetes & Cancers, A Hidden Link’.
UGR researchers show that just 5 months of exercise can reduce fat and cardiovascular risk in obese children
March 3, 2024 / UGR / Cardiovascular Risk / Obesity
A study led by researchers from the UGR’s Department of Physical Education and Sports, in collaboration with paediatricians from the Paediatric Endocrinology Unit of the “Virgen de las Nieves” University Hospital in Granada and external national and international partners, has shown that schoolchildren who exercise improve their physical fitness and health.
Impact of newborn screening in early diagnosis of rare disease in newborns
March 4, 2024 / Rare Disease / Newborns / WHO
WHO defines a rare disease as an often debilitating lifelong disease or disorder with a prevalence of 1 or less per 1000 population. However, different countries have definitions to suit their specific requirements and in the context of their population, health care system and resources.
Metabolic product of excess niacin is linked to increased risk of cardiovascular events
March 4, 2024 / Metabolic Health / Cardiovascular Risk
A metabolic product of excess niacin promotes vascular inflammation in preclinical models and is associated with increased rates of major adverse cardiovascular events (MACE) in humans. This finding calls into question whether the mandated fortification of foods with niacin should be continued.
Metabolic health’s central role in chronic kidney disease progression: a 20-year study of obesity-metabolic phenotype transitions
March 4, 2024 / Metabolic Health / Chronic Kidney Disease / Obesity
This study investigates the risk of chronic kidney disease (CKD) across four metabolic phenotypes: Metabolically Healthy-No Obesity (MH-NO), Metabolically Unhealthy-No obesity (MU-NO), Metabolically Healthy-Obesity (MH-O), and Metabolically Unhealthy-Obesity (MU-O). Data from the Tehran Lipid and Glucose Study, collected from 1999 to 2020, were used to categorize participants based on a BMI ≥ 30 kg/m2 and metabolic health status, defined by the presence of three or four of the following components: high blood pressure, elevated triglycerides, low high-density lipoprotein, and high fasting blood sugar.
User-Pay Pharmacare: A Strategic Response to Metabolic Syndrome’s Escalating Crisis
March 4, 2024 / Metabolic Syndrome / Diabetes
As Metabolic Syndrome (MetS) continues to surge, affecting an astonishing seven out of eight North Americans, the call for innovative healthcare solutions has never been more urgent. The celebrated clinician and researcher, Peter Attia, has identified MetS as the leading precursor to ‘the four horsemen of chronic disease,’ including diabetes, cardiovascular diseases, cancer, and cognitive diseases. This alarming trend not only threatens the health and wellbeing of millions but also imposes a significant financial burden on healthcare systems.
Next-Gen FibroScan Improvements Increase Speed, Ease of Liver Scans
March 4, 2024 / Next-Gen / Liver Disease
The newly released iteration of the transient elastography device FibroScan (Echosens) includes new upgrades to its user interface and scanning technologies to expedite results and make the process easier for clinicians and patients, according to the company.
FDA Grants Review Date For Applied Therapeutics’ First Commercial Product For Rare Metabolic Disorder
February 28, 2024 / FDA / Metabolic Disorder
Applied Therapeutics Inc (NASDAQ:APLT) shares are trading higher on Wednesday after the FDA accepted the filing of the New Drug Application (NDA) for govorestat (AT-007) for Classic Galactosemia.
Effects of high-protein diets on the cardiometabolic factors and reproductive hormones of women with polycystic ovary syndrome: a systematic review and meta-analysis
February 29, 2024 / Cardiometabolic / Women’s Health / PCOS
The optimal dietary regimen for polycystic ovary syndrome (PCOS) has not been identified. High-protein diets (HPDs) are effective for weight control in individuals with metabolic abnormalities, but no systematic meta-analyses have yet summarised the effects of HPDs on PCOS.
Health: Medical advances improve treatment for kidney disease patients
February 29, 2024 / Kidney Disease / Metabolic Health
Jonathan Samuel Chávez Iníguez, Director of the Adult Nephrology Department of the Civilian Hospital “Fre Antonio Alcalde”, highlighted the advancements in the care of patients with chronic kidney disease.he shared Recently, drugs developed to improve early diagnosis for patients.
Prescription Health: Cardiac specialist raising awareness on new type of heart disease
February 29, 2024 / Heart Disease / Metabolic Health
“I have high blood pressure,” Heywood — an advanced heart failure specialist at the Scripps Clinic — said, “I don’t have any cardiovascular disease, but I have some of the beginning parts of this, and probably a hundred million people in the United States have some degree of this.”.
Total dietary fiber intake is inversely associated with metabolically unhealthy status in adolescents with excess weight
February 29, 2024 / Metabolic Health / Obesity / Children
Little is known about the relationship between dietary fiber and metabolic health status in adolescents. This study was performed to investigate total dietary fiber intake and metabolic health status in a sample of Iranian adolescents with overweight/obesity. We hypothesized that higher total dietary fiber intake would reduce odds of metabolically unhealthy status.
Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study
February 29, 2024 / Women’s Health / Breast Cancer
Despite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer.
The weight-loss-independent benefits of fasting
March 1, 2024 / Obesity / Metabolic Health
In this study in humans, the authors describe distinct phases of adaptions in the plasma proteome to seven days without food, and identify limited associations of protein changes with weight loss.
Assessment of a one-week ketogenic diet on brain glycolytic metabolism and on the status epilepticus stage of a lithium–pilocarpine rat model
March 1, 2024 / Metabolic Disease / Epilepsy
The ketogenic diet (KD) has been shown to be effective in refractory epilepsy after long-term administration. However, its interference with short-term brain metabolism and its involvement in the early process leading to epilepsy remain poorly understood. This study aimed to assess the effect of a short-term ketogenic diet on cerebral glucose metabolic changes, before and after status epilepticus (SE) in rats, by using [18F]-FDG PET.
User-Pay Pharmacare: A Strategic Response to Metabolic Syndrome’s Escalating Crisis
March 4, 2024 / Metabolic Syndrome / Healthcare
As Metabolic Syndrome (MetS) continues to surge, affecting an astonishing seven out of eight North Americans, the call for innovative healthcare solutions has never been more urgent. The celebrated clinician and researcher, Peter Attia, has identified MetS as the leading precursor to ‘the four horsemen of chronic disease,’ including diabetes, cardiovascular diseases, cancer, and cognitive diseases.
Next-Gen FibroScan Improvements Increase Speed, Ease of Liver Scans
March 4, 2024 / Next-Gen FibroScan / Liver Disease
The newly released iteration of the transient elastography device FibroScan (Echosens) includes new upgrades to its user interface and scanning technologies to expedite results and make the process easier for clinicians and patients, according to the company.